1
Wei Dong Tian, Pierre Trepagnier: Generation of spatially-averaged excitation-emission map in heterogeneous tissue. Argose, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, July 22, 2003: US06597932 (276 worldwide citation)

An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue s ...


2
Pierre Trepagnier: Asynchronous fluorescence scan. Argose, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, October 28, 2003: US06639668 (262 worldwide citation)

The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention ...


3
Jonathan M Rothberg, Joel S Bader, Scott B Dewell, Keith McDade, John W Simpson, Jan Berka, Christopher M Colangelo: Method of sequencing a nucleic acid. 454 Life Sciences Corporation, Ivor R Elrifi Esq, Mintz Levin Cohn Ferris Glovsky and Popeo PC, July 17, 2007: US07244559 (190 worldwide citation)

Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.


4
Jonathan M Rothberg, Joel S Bader, Scott B Dewell, Keith McDade, John W Simpson, Jan Berka, Christopher M Colangelo: Method of sequencing a nucleic acid. 454 Life Sciences Corporation, Ivor R Elrifi Esq, Mintz Levin Cohn Ferris Glovsky and Popeo PC, September 4, 2007: US07264929 (169 worldwide citation)

Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.


5
Jonathan M Rothberg, Joel S Bader, Scott B Dewell, Keith McDade, John W Simpson, Jan Berka, Christopher M Colangelo: Method of sequencing a nucleic acid. 454 Life Sciences Corporation, Ivor R Elrifi Esq, Mintz Levin Cohn Ferris Glovsky and Popeo PC, May 1, 2007: US07211390 (152 worldwide citation)

Disclosed herein are methods and apparatuses for sequencing a nucleic acid. In one aspect, the method includes annealing a population of circular nucleic acid molecules to a plurality of anchor primers linked to a solid support, and amplifying those members of the population of circular nucleic acid ...


6
Yi Ju Chen, John H Leamon, Kenton L Lohman, Michael T Ronan, Jonathan M Rothberg, Maithreyan Srinivasan, Michael P Weiner: Double ended sequencing. 454 Life Sciences Corporation, Ivor R Elrifi Esq, Mintz Levin Cohn Ferris Glovsky and Popeo PC, July 17, 2007: US07244567 (136 worldwide citation)

This invention relates to methods of sequencing DNA. More specifically, this invention relates to methods of sequencing both the sense and antisense strands of DNA through the use of blocked and unblocked sequencing primers. In brief, these methods include the steps of annealing an unblocked primer ...


7
Jonathan M Rothberg, Joel S Bader, Scott B Dewell, Keith McDade, John W Simpson, Jan Berka, Christopher M Colangelo, Michael P Weiner: Apparatus and method for sequencing a nucleic acid. 454 Life Sciences Corporation, Ivor R Elrifi Esq, Mintz Levin Cohn Ferris Glovsky and Popeo PC, February 26, 2008: US07335762 (126 worldwide citation)

Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.


8
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: Neural transplantation using proliferated multipotent neural stem cells and their progeny. NeuroSpheres Holdings, Ivor R Elrifi Esq, Christine V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, December 24, 2002: US06497872 (101 worldwide citation)

The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural stem cell in a culture medium containing o ...


9
Dov Maor, Javier Grinfeld, Kullervo Hynynen: Ultrasound therapy. Brigham and Women&apos s Hospital, InSightec Image Guided Treatment, Ivor R Elrifi Esq, Shane H Hunter Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, September 2, 2003: US06612988 (95 worldwide citation)

The invention provides a method of delivering ultrasound signals. The method includes providing an image of at least a portion of a subject intended to receive ultrasound signals between sources of the ultrasound signals and a desired region of the subject for receiving focused ultrasound signals, i ...


10
Edith Mathiowitz, Yong Shik Jong, Kim Boekelheide: Polymeric gene delivery system. Brown University Research Foundation, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, September 16, 2003: US06620617 (85 worldwide citation)

A means for obtaining efficient introduction of exogenous genes into a patient, with long term expression of the gene, is disclosed. The gene, under control of an appropriate promoter for expression in a particular cell type, is encapsulated or dispersed with a biocompatible, preferably biodegradabl ...



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