1
Robert C Ladner, Sonia K Guterman, Bruce L Roberts, William Markland, Arthur C Ley, Rachel B Kent: Directed evolution of novel binding proteins. Protein Engineering, Iver P Cooper, June 29, 1993: US05223409 (1672 worldwide citation)

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore o ...


2
Robert C Ladner, Sonia K Guterman, Bruce L Roberts, William Markland, Arthur C Ley, Rachel B Kent: Viruses expressing chimeric binding proteins. Protein Engineering Corporation, Iver P Cooper, April 4, 1995: US05403484 (766 worldwide citation)

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore o ...


3
Robert C Ladner, Sonia K Guterman, Bruce L Roberts, William Markland, Arthur C Ley, Rachel B Kent: Directed evolution of novel binding proteins. Protein Engineering Corporation, Iver P Cooper, November 5, 1996: US05571698 (694 worldwide citation)

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore o ...


4
Thomas E Wagner, Peter C Hoppe: Genetic transformation of zygotes. Ohio University, Iver P Cooper, Donald G Leavitt, October 10, 1989: US04873191 (448 worldwide citation)

Genetic transformation of a zygote and the embryo and mature organism which result therefrom is obtained by placing or inserting exogenous genetic material into the nucleus of the zygote or into any genetic material which ultimately forms at least a part of the nucleus of the zygote. It is preferred ...


5
Robert C Ladner, Sonia K Guterman, Rachel B Kent, Arthur C Ley: Generation and selection of novel DNA-binding proteins and polypeptides. Protein Engineering Corporation, Iver P Cooper, March 17, 1992: US05096815 (249 worldwide citation)

Novel DNA-binding proteins, especially repressors of gene expression, are obtained by variegation of genes encoding known binding protein and selection for proteins binding the desired target DNA sequence. A novel selection vector is used to reduce artifacts. Heterooligimeric proteins which bind to ...


6
Robert C Ladner, Sonia K Guterman, Rachel B Kent, Arthur C Ley: Generation and selection of novel DNA-binding proteins and polypeptides. Protein Engineering, Iver P Cooper, March 30, 1993: US05198346 (220 worldwide citation)

Novel DNA-binding proteins, especially repressors of gene expression, are obtained by variegation of genes encoding known binding proteins and selection for proteins binding the desired target DNA sequence. A novel selection vector may be used to reduce artifacts. Heterooligomeric proteins which bin ...


7
Frederick J Darfler: Cell culture medium with antioxidant. Cell Enterprises, Iver P Cooper, May 22, 1990: US04927762 (197 worldwide citation)

Cells grown in chemically defined (serum free) media are protected against endogenous oxidizing agents by a nontoxic antioxidant with free thiol groups, at cell densities less than about 10.sup.5 cells/ml, especially DL-penicillamine, N-acetylcysteine, mercaptoproprionic acid, 2-mercaptoethanesulfon ...


8
Robert Charles Ladner, Sonia Kosow Gutterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent: Directed evolution of novel binding proteins. Dyax, Iver P Cooper, November 17, 1998: US05837500 (191 worldwide citation)

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore o ...


9
John K McGeehan, Gerhard Ertingshausen: Method and device for metering of fluid samples and detection of analytes therein. Actimed Laboratories, Iver P Cooper, August 10, 1993: US05234813 (134 worldwide citation)

An analytical device for fluid samples includes a fluid sample well means connected to a sample initiation area in such a fashion that the assay will not commence unless sufficient sample is introduced into the sample well means to conduct the assay. Once sufficient sample has been deposited into th ...


10
Stephen L Hoffman, Kiyoshi Nagai: Blood substitutes. Somatogenetics International, Iver P Cooper, July 2, 1991: US05028588 (99 worldwide citation)

Solutions of mutant hemoglobins having a lower oxygen affinity than that of native hemoglobin are used as blood substitutes. The mutant hemoglobins are preferably obtained by recombinant DNA techniques. Both alpha and beta globin chains can now be so prepared, making possible the production of wholl ...