1
Leon WMM Terstappen, Gerald Dolan: Magnetic separation apparatus and methods. Joseph F Aceto, Immunicon Corporation, June 24, 2004: US20040118757-A1

Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic ca ...


2
Michael Kagan, Galla Chandra Rao, Jerry Prohaska, Tor Alden: Upon a cartridge for containing a specimen sample for optical analysis. Joseph E Aceto PhD JD, Immunicon Corporation, May 27, 2004: US20040101443-A1

An improved cartridge for holding a fluid sample with a small volume is disclosed herein. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. Improved grips are flared-out to aid manipulation. The handle portion is reinforced to prevent ...


3
Arjan Tibbe, Jan Greve, Leon WMM Terstappen, Bart De Grooth: Devices and methods to image objects. Immunicon Corporation, January 6, 2005: US20050003464-A1

Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected ...


4
Richard L Columbus: Cartridge for containing a specimen sample for optical analysis. Immunivest Corporation, Immunicon Corporation, March 24, 2005: US20050063863-A1

A cartridge for holding a test specimen with an extremely small volume. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. The cartridge has a stopper having a pair of seals, the first of which seals the test chamber inlet between the v ...


5
Jeffrey W Allard, Massimo Cristofanilli, Leon WMM Terstappen: Circulating tumor cells (CTCs): early assessment of time to progression, survival and response to therapy in metastatic cancer patients. Immunicon Corporation, February 15, 2007: US20070037173-A1

A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell SpotterĀ® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epit ...


6
Mark Carle Connelly, Gerald V Doyle, Galla Chandra Rao, Leon WMM Terstappen: Method for assessing disease states by profile analysis of isolated circulating endothelial cells. Immunicon Corporation, July 5, 2007: US20070154960-A1

Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ trans ...


7
Tycho M Scholtens, Leon LMM Terstappen, Arjan GJ Tibbe: Magnetic separation apparatus and methods. Immunicon Corporation, November 16, 2006: US20060257847-A1

Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic ca ...


8
Teresa Bendele, Thomas Harbart, Dave Howard, Michael Kagan, Douglas Keene, Dave Lapeus, Jared Mayes, Douglas Paynter, Jerry Prohaska, Herman Rutner: Operator independent programmable sample preparation and analysis system. Immunicon Corporation, September 13, 2007: US20070212698-A1

The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously ...


9
Frank AW Coumans, Arthur G Marlin, Frank P Modica, John V Verrant: Diagnostic imaging device for the analysis of circulating rare cells. Immunicon Corporation, July 5, 2007: US20070153280-A1

The present invention provides a system for imaging circulating tumor cells from blood after enrichment. The system is designed to provide optimum use in a clinical laboratory setting with minimum laboratory bench top space. Operator intervention is minimized compared to other analytical methodologi ...


10
Leon WMM Terstappen, Gerald Dolan: Magnetic separation apparatus and methods. Joseph F Aceto and James Wilcox, Immunicon Corporation, January 8, 2004: US20040004043-A1

Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic ca ...