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Andrew J Murphy, Sean Stevens, Chozhavendan Rathinam, Elizabeth Eynon, Markus Manz, Richard Flavell, George D Yancopoulos: Humanized M-CSF mice. Regeneron Pharmaceuticals, Yale University, Institute for Research in Biomedicine, Tor Smeland, Ilona Gont, Michael B Rubin, May 23, 2017: US09655352 (3 worldwide citation)

Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and met ...


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Sean Stevens, Andrew J Murphy, Richard Flavell, Elizabeth Eynon, Jorge Galan, Tim Willinger, Markus Manz, Anthony Rongvaux, George D Yancopoulos: Genetically modified mice and engraftment. Regeneron Pharmaceuticals, Yale University, Institute for Research in Biomedicine, Tor Smeland, Ilona Gont, Michael B Rubin, January 31, 2017: US09554563 (3 worldwide citation)

A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells ( ...


3
John McWhirter, Lynn Macdonald, Joel H Martin, Andrew J Murphy: Non-human animals expressing pH-sensitive immunoglobulin sequences. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Ilona Gont, October 31, 2017: US09801362

Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a hisidine codon, or the insertion of ...


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John McWhirter, Lynn MacDonald, Joel H Martin, Andrew J Murphy: Non-human animals expressing pH-sensitive immunoglobulin sequences. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Ilona Gont, May 16, 2017: US09648856

Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a histidine codon, or the insertion of ...


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John McWhirter, Cagan Gurer, Karolina A Meagher, Lynn Macdonald, Andrew J Murphy: Non-human animals with modified immunoglobulin heavy chain sequences. Regeneron Pharmaceuticals, Rita S Wu, Ilona Gont, Elysa Goldberg, April 3, 2018: US09930871

Non-human animals, e.g., mammals, e.g., mice or rats, are provided comprising an immunoglobulin heavy chain locus that comprises a rearranged human immunoglobulin heavy chain variable region nucleotide sequence. The rearranged human immunoglobulin heavy chain variable region nucleotide sequence may ...


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Richard Flavell, Till Strowig, Markus G Manz, Chiara Borsotti, Madhav Dhodapkar, Andrew J Murphy, Sean Stevens, George D Yancopoulos: Genetically modified non-human animals and methods of use thereof. Regeneron Pharmaceuticals, Yale University, Institute for Research in Biomedicine, Tor Smeland, Ilona Gont, Michael B Rubin, February 27, 2018: US09901082

Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically mod ...


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Dietmar Herndler Brandstetter, Richard A Flavell, Davor Frleta, Cagan Gurer, Markus Gabriel Manz, Andrew J Murphy, Noah W Palm, Liang Shan, Sean Stevens, Till Strowig, George D Yancopoulos, Marcel de Zoete: Genetically modified non-human animals and methods of use thereof. Regeneron Pharmaceuticals, Yale University, Institute For Research In Biomedicine, Tor Smeland, Ilona Gont, Michael B Rubin, November 13, 2018: US10123518

Genetically modified non-human animals expressing human SIRPĪ± and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPĪ± and human IL-15 from the non-human animal genome, and methods for using non-human animals express ...


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Lynn Macdonald, Sean Stevens, Andrew J Murphy: Mice that make heavy chain antibodies. REGENERON PHARMACEUTICALS, Brownstein Hyatt Farber Schreck, Rita S Wu, Ilona Gont, February 13, 2018: US09888675

Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion in an immunoglobulin constant region CH1 gene (optionally a deletion in a hinge region) of an IgG, IgA, IgD, and/or IgE, and wherein the m ...