Ra Helton: C 10 ester substituted taxadane. Florida Stat Univ Research Fund, huang gesheng, April 28, 2004: CN01130352 (27 worldwide citation)

The present invention provides taxane with C10 ester substituent, C7 hydroxy substituent and serial C2, C9 and C14 side chain substituents.

C Monneret, E Bertounesque, P Meresse: Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them. Les Laboratoires Servier, huang gesheng gui yongliang, August 20, 2003: CN01811549 (9 worldwide citation)

The invention concerns compounds of formula (I) wherein: R1 represents a group selected among hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulphonyl, arylsulphonyl, arylalkylsulphonyl, and phosphon ...

Matias Late: Synergistic composition containing ascobic acid salt and lysine used for diseases related with extracellular substrate degeneration. Matias Late, huang gesheng, August 28, 2002: CN01111316 (8 worldwide citation)

The present invention discloses a composition for preventing and treating the diseases associated with the ectocytic matrix degradation, including retrogressive diseases, especially the atherosclerosis, cancer, infection and inflammation. It contains lysine, proline, ascorbate and its derivative and ...

Roncucci Gabrio, Dei Donata, Filippis Maria Paola de, Fantetti Lia, Nistri Daniele: Metal substituted non centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic. Molteni &Amp C Dei Flii Alitti So, huang gesheng, June 29, 2005: CN02806846 (3 worldwide citation)

Phthalocyanine analogues having an active group able to link the phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier conjugates showing enhanced photodynamic properties, red shifted absorption characteristic, all useful for photodynamic therapy, are described. ...

W Staehle, S Goodman: Biphenyl derivatives and use thereof as integrin inhibitors. Merck Patent, huang gesheng liu jinhui, October 8, 2003: CN01814415 (3 worldwide citation)

Novel biphenyl derivatives of the general formula (I), in which Y, R R, R, R, R, m, o and p are as defined in claim 1, and their physiologically acceptable salts and solvates are integrin inhibitors and can be employed for combating thrombosis, cardiac infarction, coronary heart disease, arterioscle ...

Atwell Graham J, Denny William A, Wilson William R, Yang Shangjin: Nitroaniline-based alkylating agents and their use as prodrugs. Auckland Uniservices, huang gesheng lin bainan, December 21, 2005: CN200380102812 (2 worldwide citation)

Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjunction with nitroreductase enzymes as hypoxia selective cy ...

Buchdunger Elisabeth, Capdeville Renaud, Demetri George Daniel: Treatment of gastrointestinal stromal tumors. Novartis, huang gesheng lin bainan, June 1, 2005: CN01817895 (2 worldwide citation)

The invention discloses 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino]phenyl]-benzamide of the formula I or a pharmaceutically acceptable salt thereof can be used in the treatment of gastrointestinal stromal tumours.

Hoelder Swen, Naumann Thorsten, Schoenafinger Karl, Will David William, Matter Hans, Mueller Guenter, Le Suisse Dominique, Baudoin Bernard, Rooney Thomas, Halley Franck, Tiraboschi Gilles, Combeau Cecile, Sassoon Ingrid, Steinmetz Anke: Pyridazinone derivatives as gsk-3beta inhibitors. Aventis Pharma, huang gesheng sui xiaobeng, March 1, 2006: CN200380105057 (2 worldwide citation)

The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl, aryl (C1-C10-alkyl)-, heteroaryl, heteroaryl-(C1-C10-alkyl)-, heterocyclyl, heterocyclyl-(C1-C10-alkyl)-, C3-C10-cycloa ...

Rl Arslanian, G Ashley, S Frykman: Production of polyketides. Kosan Biosciences, huang gesheng lin bainan, July 7, 2004: CN01808711 (2 worldwide citation)

Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.

Jj Seaman, B Garry, H Schran: Use of zolendronate for mfg. medicament for treatment of bone metabolism diseases. Novartis, huang gesheng liu jinhui, March 10, 2004: CN01809781 (2 worldwide citation)

A method of intravenously administering a bisphosphonate to a patient in need of bisphosphonate treatment comprising intravenously administering 4 mg of 2-(imidazol-1yl)-1-hydroxyethane-1,1-diphosphonic acid (zoledronic acid) or a pharmaceutically acceptable salt thereof over a period of 15 minutes ...