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Flynn Gary A, Lee Sandra Aeyoung, Faris Mary, Brandt David William, Chakravarty Subrata: Intracellular kinase inhibitors. Mannkind Corporation, Flynn Gary A, Lee Sandra Aeyoung, Faris Mary, Brandt David William, Chakravarty Subrata, HEMMENDINGER Lisa M, November 29, 2007: WO/2007/136790 (74 worldwide citation)

Intracellular kinase inhibitors and their therapeutic uses for patients with T cell malignancies, B cell malignancies, autoimmune disorders, and transplanted organs.


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Scarselli Maria, Bensi Giuliano, Grandi Guido: Immunogenic and therapeutic compositions for streptococcus pyogenes. Novartis, Scarselli Maria, Bensi Giuliano, Grandi Guido, HEMMENDINGER Lisa M, September 12, 2008: WO/2008/108830 (19 worldwide citation)

Compositions for preventing and/or treating S. pyogenes infection which comprise one or more active agents. The active agents are SLO antigens, nucleic acid molecules encoding the SLO antigens, and/or antibodies which selectively bind to the SLO antigens.


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Firestone Leigh H: Compositions and methods for treating menopausal females. Firestone Leigh H, HEMMENDINGER Lisa M, June 11, 2009: WO/2009/073788 (13 worldwide citation)

Compositions comprising vanilloid receptor ligands are used for treating human females experiencing symptoms of menopause. The vanilloid receptor ligand composition can be a sustained release formulation of the drug in order to control the release of the drug to the patient over an extended period o ...


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Zhang Jin, Dipilato Lisa Marie: Camp reporters. The Johns Hopkins University, Zhang Jin, Dipilato Lisa Marie, HEMMENDINGER Lisa M, March 2, 2006: WO/2006/023972 (9 worldwide citation)

cAMP reporters useful for obtaining measurements of cAMP levels with high spatial and temporal resolution.


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Schloss John Vinton, Lobl Thomas Jay: Formulations. Neurosystec Corporation, Schloss John Vinton, Lobl Thomas Jay, Hemmendinger Lisa M, December 23, 2009: WO/2009/155401 (8 worldwide citation)

Colloidal suspensions comprising a therapeutic agent and squalene. Squalene binds to certain compounds, such as gacyclidine, much more tightly than other drug carriers, such as polylactic glycolic acid. Including squalene in the particulate phase sequesters the therapeutic agent and provides superio ...


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Greenwalt Dale: Methods and tools for detecting collagen degradation. Cambrex Bio Science Walkersville, Greenwalt Dale, HEMMENDINGER Lisa M, December 1, 2005: WO/2005/113794 (7 worldwide citation)

Fluorophore-labeled collagen covalently bound to a cell culture vessel can be used to assay collagen degradation by a variety of cell types, including osteoclasts and tumor cells. Such assays provide a high throughput platform for rapid screening of large numbers of potential modulators of, for exam ...


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Pannuri Sachin, Kamat Sanjayt Venkatesh, Garcia Abraham Rogelio Martin: Thermostable omega-transaminases. Cambrex North Brunswick, Pannuri Sachin, Kamat Sanjayt Venkatesh, Garcia Abraham Rogelio Martin, HEMMENDINGER Lisa M, June 15, 2006: WO/2006/063336 (6 worldwide citation)

Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a air of chiral am ...


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Karas Michael: Intracellular delivery of small molecules proteins and nucleic acids. Biowhittaker Technologies, Karas Michael, HEMMENDINGER Lisa M, September 16, 2004: WO/2004/078933 (4 worldwide citation)

An amino acid sequence Arg-Lys-Met-Leu-Lys-Ser-Thr-Arg-Arg-Gln-Arg-Arg (SEQ ID NO: 1) functions as a protein transduction domain (PTD) and is capable of delivering small molecules, proteins, and nucleic acids to an intracellular compartment of a cell. An amino terminal lysine linker improves the eff ...


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Hermiston Terry, Kuhn Irene: Generation of oncolytic adenoviruses and uses thereof. Bayer Schering Pharma Aktiengesellschaft, Hermiston Terry, Kuhn Irene, HEMMENDINGER Lisa M, July 3, 2008: WO/2008/080003 (3 worldwide citation)

The present invention relates to a method for the production of oncolytic adenoviruses having increased potency and their therapeutic applications for cancer. Recombinant adenoviruses and methods to produce them are provided.