1
Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J Craig Venter: antigens and compositions. Novartis Vaccines and Diagnostics, Amy Hessler, Helen Lee, Robert Gorman, August 18, 2009: US07576176 (45 worldwide citation)

The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.


2
Derek O Hagan, Manmohan Singh, Janet Wendorf, Jina Kazzaz, Padma Malyala: Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions. Novartis, Helen Lee, David B Bonham, April 30, 2013: US08431160 (36 worldwide citation)

Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof ...


3
Audino Podda, Nicola Groth, Michele Pellegrini: Adjuvanted influenza vaccines for pediatric use. Novartis, Helen Lee, Otis Littlefield, August 13, 2013: US08506966 (35 worldwide citation)

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence ...


4
Derek O Hagan, Manmohan Singh: Compositions for inducing immune responses. Novartis Vaccines and Diagnostics, Helen Lee, David Bonham, Robert Gorman, June 8, 2010: US07731967 (33 worldwide citation)

The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said firs ...


5
Astrid Borkowski: Multiple vaccination including serogroup C meningococcus. Novartis Vaccines and Diagnostics, Helen Lee, Otis Littlefield, May 21, 2013: US08444992 (31 worldwide citation)

Various improvements to vaccines that include a serogroup C meningococcal conjugate antigen, including: (a) co-administration with acellular B. pertussis antigen; (b) co-administration with an inactivated poliovirus antigen; (c) supply in a kit together with a separate pneumococcal conjugate compone ...


6
Derek O Hagan, Gary S Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman: Microemulsions with adsorbed macromolecules and microparticles. Novartis, Helen Lee, David Bonham, May 27, 2014: US08734832 (29 worldwide citation)

Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using ...


7
Vega Masignani, Marirosa Mora, Maria Scarselli: proteins and nucleic acids. Novartis Vaccines and Diagnostics, Helen Lee, Lisa Hemmendinger, October 27, 2009: US07608276 (21 worldwide citation)

The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.


8
Derek O Hagan, Gary Van Nest, Gary S Ott, Manmohan Singh: Use of microparticles combined with submicron oil-in-water emulsions. Novartis Vaccines and Diagnostics, Helen Lee, Roberta L Robins, Robert Gorman, September 20, 2011: US08021834 (14 worldwide citation)

Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b ...


9
Derek O Hagan, Manmohan Singh: Method of obtaining cellular immune responses from proteins. Novartis Vaccines and Diagnostics, Helen Lee, David Bonham, Robert Gorman, October 20, 2009: US07604802 (13 worldwide citation)

A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a pharmaceutically acceptable excipient is disclosed.


10
Rino Rappuoli: Conserved Neisserial antigens. Novartis Vaccines and Diagnostics, Amy Hessler, Helen Lee, Robert Gorman, October 20, 2009: US07604810 (10 worldwide citation)

To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides proteins which comprise stretches of amino acid sequence that are shared across the majority of Neisseria ...



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