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Ziober Barry L, Bau Haim H, Mauk Michael G, Chen Zongyuan, Wang Jing: Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease. Trustees Of The University Of Pennsylvania, Ziober Barry L, Bau Haim H, Mauk Michael G, Chen Zongyuan, Wang Jing, HAGAN Patrick J, August 16, 2007: WO/2007/092713 (21 worldwide citation)

Biomarkers for the detection of pre-cancer and cancer cells and a method for their detection at the point of care are disclosed. The system is comprised of an inexpensive, disposable microfluidic cassette for sample preparation; continuous-flow, magnetic-bead assisted cell sorting and cytometry; cel ...


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Weber Lutz, Khazak Vladimir, Ross Gunther, Kalinski Cedric, Burdack Christoph: Novel tetrahydro-isoquinolines. Nexuspharma, Weber Lutz, Khazak Vladimir, Ross Gunther, Kalinski Cedric, Burdack Christoph, HAGAN Patrick J, March 20, 2008: WO/2008/034039 (11 worldwide citation)

The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating ...


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Condon Stephen M, Jackson Randy William, Laporte Matthew G, Burns Christopher J, Herbertz Torsten, Gaboury Janet A: Pyranoindole derivatives and the use thereof for the treatment of hepatitis c virus infection or disease. Viropharma Incorporated, Wyeth, Condon Stephen M, Jackson Randy William, Laporte Matthew G, Burns Christopher J, Herbertz Torsten, Gaboury Janet A, HAGAN Patrick J, September 15, 2005: WO/2005/084315 (9 worldwide citation)

The invention is directed to novel pyranoindole derivatives and analogs as well as compositions containing the same and to the use thereof for the treatment, prevention or inhibition of viral infections and associated diseases caused by the Hepatitis C virus.


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Villano Stephen A, Howe Anita Y M: Combination therapy method for treating hepatitis c virus infection and pharmaceutical compositions for use therein. Viropharma Incorporated, Wyeth, Villano Stephen A, Howe Anita Y M, HAGAN Patrick J, February 28, 2008: WO/2008/024843 (6 worldwide citation)

Combination therapy methods for the treatment of hepatitis C virus infection and associated diseases, by the co-administration of 5-cyclopropyl-2- (4-fluoro-phenyl-6-[(2-hydroxy-ethyl)-methanesulfonyl-amino]-benzofuran- 3-carboxylic acid methylamide or a pharmaceutically acceptable salt thereof with ...


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Matias Jonathan R: Menthol propyleneglycol-carbonate and analogs thereof as insect pest repellents.. Poseidon Ocean Sciences, Matias Jonathan R, HAGAN Patrick J, March 24, 2005: WO/2005/025313 (5 worldwide citation)

Menthol propyleneglycol-carbonate, analogs thereof and compositions containing such compounds are useful as insect repellents.


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Bailey Thomas R: Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases. Viropharma Incorporated, Wyeth, Bailey Thomas R, HAGAN Patrick J, December 1, 2005: WO/2005/112640 (5 worldwide citation)

Disclosed are novel benzofuran, naphthalene, benzimidazole, benzothiophene, isoindole, and indole derivatives and analogs thereof, as well as compositions containing the same and, the use thereof for the treatment of prophylaxis of viral infections and diseases associated therewith, particularly tho ...


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Bailey Thomas R, Pevear Daniel C: Benzothiazole compounds, compositions and methods for treatment and prophylaxis of rotavirus infections and associated diseases. Viropharma Incorporated, Bailey Thomas R, Pevear Daniel C, HAGAN Patrick J, September 16, 2004: WO/2004/078115 (3 worldwide citation)

Methods of using benzothiazole derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the rotavirus.


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