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Tassopoulos Nic C, Hatzakis Angelos E, Troonen Hugo, Kuhns Mary C: Non-a, non-b, non-c, non-d, non-e hepatitis reagents and methods for their use. Abbott Laboratories, Tassopoulos Nic C, Hatzakis Angelos E, Troonen Hugo, GORMAN Edward H Jr, August 18, 1994: WO/1994/018217 (1 worldwide citation)

Hepatitis G Virus (HGV) nucleic aic sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGV nucleic acid sequences, HGV immunogenic particles, and a method for producing antibodies to HGV. Also provided are methods for producing antibodies, polyclonal or mon ...


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Cunningham David D: Composite membrane. Abbott Laboratories, GORMAN Edward H Jr, July 8, 1993: WO/1993/013408 (1 worldwide citation)

A sensor device (400) for measuring the concentration of an analyte in solution is described. The device (400) includes a composite membrane (440) which incorporates a porous membrane (442) containing an immobilized biologically-active protein and at least one other membrane. The other membrane may ...


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Frederick Waren P, Helgren R Hayes, Kruger Robert J, Larkin Mark E: Fluid port reseal member. Abbott Laboratories, GORMAN Edward H Jr, July 6, 1995: WO/1995/017873

This invention pertains to a reseal member made of a soft elastomeric material used for sealing a fluid access port. The reseal member is inserted into the fluid access port and prevents fluids from passing therethrough. The reseal member is provided with a slit or recess, or both, that allows a use ...


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Murad Ferid, Kerwin James F, Gorsky Lee D: Guanidine compounds as regulators of nitric oxide synthase. Abbott Laboratories, GORMAN Edward H Jr, October 26, 1995: WO/1995/028377

Guanidine compounds of formula (I) or a pharmaceutically-acceptable salt, ester, amide or prodrug thereof, which are regulators of nitric oxyde synthase and are useful in the treatment of disorders of the vascular system including hypotension, hypertension, shock, atherosclerosis, migraine, or ische ...


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Pope Mark R, Bieniarz Christopher: Reagents and methods for the determination of glycohydrolytic enzymes. Abbott Laboratories, GORMAN Edward H Jr, August 5, 1993: WO/1993/015097

Novel pyrene-trisulfonate derivatives and the use thereof in a method for the determination of glycohydrolitic enzyme activity are provided. The method comprises the steps of (a) forming a test solution comprising a test sample containing the glycohydrolitic enzyme and a pyrene-trisulfonate derivati ...


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Casey James M, Bode Suzanne L, Zeck Billy J, Yamaguchi Julie, Frail Donald E, Desai Suresh M, Devare Sushil G: Mammalian expression systems for hcv proteins. Abbott Laboratories, GORMAN Edward H Jr, August 5, 1993: WO/1993/015193

Mammalian expression systems for the production of HCV proteins. Such expression systems provide high yields of HCV proteins, and enable the development of diagnostic and therapeutic reagents which contain glycosylated structural antigens and also allow for the isolation of the HCV etiological agent ...


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Brill Gregory M, Burres Neal S, Chen Randal H, Humphrey Patrick E, Mcalpine James B, Rasmussen Ronald R: Antifungal compounds. Abbott Laboratories, GORMAN Edward H Jr, November 11, 1993: WO/1993/021770

Novel compounds having structural formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein one of R?1¿ and R?2¿ is hydrogen and the other is -CH=CHCOOH, X is >CH-, and Y is -O-; or, alternatively, the bond between X and Y is not present, X is -CH¿2?-, and Y is -OH, as well as ...


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Mattingly Phillip G: Haptens, tracers, immunogens and antibodies for acridine-9-carboxylic acids. Abbott Laboratories, Mattingly Phillip G, GORMAN Edward H Jr, October 14, 1993: WO/1993/020074

Novel haptens and related conjugates based on acridine-9-carboxylic acid, as well as methods for making and using such conjugates. Haptens based on the above core structure may be substituted at positions 3 or 6. Using tethered intermediates, immunogens, tracers, solid supports and labeled oligonucl ...


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Coleman Carole Lynn, Genger Kevin Reinhold, Graham Hugh William, Hanna Charles Francis, Khalil Omar Soliman, Wender David C: Improved device for automated chemiluminescent immunoassays. Abbott Laboratories, GORMAN Edward H Jr, November 10, 1994: WO/1994/025160

An improved device is used for performing solid-phase chemiluminescent immunoassays. The device comprises a container having a fibrous matrix and a porous absorbent material. An improvement in the device is the use of light absorbing material as the absorbent material or as a light barrier between t ...