1
Rainer Alex, Paul Hadvary, Hansjorg Tschirky: Dermally affixed injection device. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, August 3, 1999: US05931814 (484 worldwide citation)

An improved injection device has a casing containing an active substance reservoir, a cannula communicating with the reservoir, a device for inserting the cannula, and pump means for discharging the reservoir contents through the cannula. The cannula 11 is fixed relative to the casing and projects b ...


2
Giorgio Cirelli, Benno Rothenhausler, Hans Steffen: Device for introducing active substance into a patient. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, December 15, 1998: US05848990 (213 worldwide citation)

A device for introducing an active substance solution into a patient and with means for fastening to the skin and a cannula. The cannula is held in a withdrawn position by a retaining and releasing mechanism before use and, after release, is propelled into the patient's skin. A connector connected t ...


3
David H Gelfand, Pamela M Holland, Randall K Saiki, Robert M Watson: Reaction mixtures for detection of target nucleic acids. Roche Molecular Systems, George W Johnston, Patricia S Rocha Tramaloni, Stacey R Sias, September 8, 1998: US05804375 (200 worldwide citation)

A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorpo ...


4
Christof Fattinger: Microoptical sensor and method. Hoffmann La Roche, George M Gould, George W Johnston, October 3, 1995: US05455178 (171 worldwide citation)

A microoptical sensor and a corresponding method for detecting chemical substances in a sample. The sample is brought into contact with the waveguiding layer of a planar optical waveguide. Coherent light is coupled into the waveguiding layer, propagates therein as a guided wave, and the latter is de ...


5
Martin Schadt, Klaus Schmitt: Optical component. Hoffmann La Roche, George W Johnston, Dennis P Tramaloni, Alan P Kass, February 11, 1997: US05602661 (171 worldwide citation)

An optical component includes an anisotropic layer of cross-linked liquid crystal monomers with varying local orientation of the liquid crystal molecules. The liquid crystal layer is in contact with an orientation layer comprising a photo-orientable polymer network (PPN). A method of making includes ...


6
Josef Burg, Bernd Hilger, Hans Peter Josel: Erythropoietin conjugates. Roche Diagnostics, George W Johnston, Dennis P Tramaloni, F Aaron Dubberley, January 22, 2002: US06340742 (165 worldwide citation)

Erythropoietin glycoprotein products are disclosed which have the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells. The present conjugates have an increased circulating half-life and plasma residence time, decreased clearance, and i ...


7
Mikhail I Barnik, Sergey V Belyaev, Jurg Funfschilling, Nikolai Malimonenko, Martin Schadt, Klaus Schmitt: Polarizer device. Hoffmann La Roche, NIOPIC Moscow Research and Production Association, George M Gould, George W Johnston, August 10, 1993: US05235443 (158 worldwide citation)

The polarizer comprises a layer of cholesteric liquid crystal with Grandjean structure disposed in the path of the light and in which the light in a given wavelength range is reflected with selective and circular polarization or is transmitted with reversed direction of rotation, and a mirror which ...


8
Jurg Funfschilling, Martin Schadt: Light control systems with a circular polarizer and a twisted nematic liquid crystal having a minimum path difference of .lambda./2. Hoffmann La Roche, George M Gould, George W Johnston, June 7, 1994: US05319478 (132 worldwide citation)

A new mode of operation is proposed for light control systems consisting of a combination of liquid crystal cells and polarizers. The direct operation of liquid crystal cells with circularly-polarized light is advantageous in many respects. The circularly-polarized light is produced either with conv ...


9
Rolf Moser, Lukas Birrer: Thermal cycler. Roche Diagnostic Systems, George W Johnston, William H Epstein, John P Parise, August 18, 1998: US05795547 (129 worldwide citation)

An apparatus for automatic performance of temperature cycles in a number of test tubes in which each test tube is closed by a closure and contains a predetermined volume of a liquid reaction mixture. The apparatus includes a holder, a computer-controlled automatic control system, and a device for cy ...


10
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Lewis J Kreisler, May 5, 1998: US05747646 (127 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...