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Kristina Marie Burow, Jeremy S Caldwell, Robert Charles Downs, Scott Allan Lesley, James Kevin Mainquist, Andrew J Meyer, Daniel G Sipes, Mark Richard Weselak: High throughput processing system and method of using. IRM, Timothy L Smith, Genomics Institute of the Novartis Research Foundation, June 24, 2008: US07390458 (103 worldwide citation)

Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work ...


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Pingda Ren, Xia Wang, Guobao Zhang, Qiang Ding, Shuli You, Qiong Zhang, Greg Chopiuk, Pamela A Albaugh, Taebo Sim, Nathanael Schiander Gray: Compounds and compositions as protein kinase inhibitors. IRM, Scott W Reid, Genomics Institute of the Novartis Research Foundation, June 29, 2010: US07745437 (17 worldwide citation)

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal act ...


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Thomas H Marsilje, Nathanael S Gray, Tao Jiang, Wenshuo Lu, Shifeng Pan: Immunosuppressant compounds and compositions. IRM, Scott W Reid, The Genomics Institute of the Novartis Research Foundation, June 13, 2006: US07060697 (16 worldwide citation)

The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particul ...


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Pierre Yves Michellys, Wei Pei, Thomas H Marsilje, Bei Chen, Tetsuo Uno: Compounds and compositions as protein kinase inhibitors. IRM, Emily Tongco Wu, Genomics Institute of the Novartis Research Foundation, October 18, 2011: US08039479 (13 worldwide citation)

The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition o ...


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Robert Charles Downs, Mark Richard Weselak, James Kevin Mainquist: Gripping mechanisms, apparatus and methods. IRM, Timothy L Smith Genomics Institute of the Novartis Research Foundation, September 9, 2008: US07422411 (13 worldwide citation)

The present invention provides grasping mechanisms, gripper apparatus/systems, and related methods. Grasping mechanisms that include stops, support surfaces, and height adjusting surfaces to determine three translational axis positions of a grasped object are provided. In addition, grasping mechanis ...


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Sheng Ding, Tom Wu, Nathanael S Gray, Peter Schultz: 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells. IRM, The Scripps Research Institute, Scott W Reid, D Phil, The Genomics Institute of the Novartis Research Foundation, August 7, 2007: US07253166 (10 worldwide citation)

The invention provides a novel class of compounds and compositions of Formula I: in which R1, R2 and R3 are defined herein, that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3β, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, ...


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Greg Chopiuk, Pascal Furet, Nathanael Schiander Gray, Patricia Imbach, Yi Liu, Joseph Schoepfer, Ruo Steensma: Methods and compositions as protein kinase inhibitors. IRM, Scott W Reid, The Genomics Institute of the Novartis Research Foundation, March 13, 2007: US07189729 (10 worldwide citation)

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal act ...


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Mark R Weselak, Brad Backes, Jared Ek: Systems and methods for sorting samples. IRM, Timothy L Smith, Genomics Institute of the Novartis Research Foundation, April 29, 2008: US07364907 (9 worldwide citation)

Methods and systems for sorting compounds and compound holders into batches for subsequent processing are provided.


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Taebo Sim, Hyun Soo Lee, Pingda Ren, Qiang Ding, Yi Liu, Bing Li, Lintong Li, Xia Wang, Tetsuo Uno, Guobao Zhang, Nathanael Schiander Gray, Shuli You: Compounds and compositions as protein kinase inhibitors. IRM, Scott W Reid D Phil, Genomics Institute of the Novartis Research Foundation, January 5, 2010: US07642255 (9 worldwide citation)

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal act ...