1

2
Ulrich Behrendt, Horst Eberhardt, Berthold Szperalski: Methods for growing mammalian cells in vitro. Hoffman La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, June 24, 2008: US07390660 (42 worldwide citation)

The invention relates to a method for reducing glucose consumption during cultivation of animal cells, which comprises cultivating animal cells in the presence of a bi- or tricarbonic acid or a salt thereof at a concentration of about 1 to 50 mmol/l.


3
Stephan Fischer, Friederike Hesse, Hendrik Knoetgen, Kurt Lang, Friedrich Metzger, Joerg Thomas Regula, Christian Schantz, Andreas Schaubmar, Hans Joachim Schoenfeld: Method for the production of conjugates of insulin-like growth factor-1 and poly(ethylene glycol). Hoffmann La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, December 1, 2009: US07625996 (12 worldwide citation)

The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. ...


4
Joachim Moecks, Andreas Strauss, Gerhard Zugmaier: Method for predicting the response to a treatment. Hoffmann La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, April 20, 2010: US07700299 (12 worldwide citation)

The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor a ...


5
Li Chen, Yun He, Jason Christopher Wong: N-(2-amino-phenyl)-amide derivatives. Hoffman La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, September 14, 2010: US07795315 (12 worldwide citation)

The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments containing such compounds. The compounds of the present invention show anti-proliferative and differentiatio ...


6
Christian Klein, Wolfgang Schaefer: Bivalent, bispecific antibodies. Hoffman La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, July 24, 2012: US08227577 (10 worldwide citation)

The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.


7
Christian Klein, Wolfgang Schaefer: Bivalent, bispecific antibodies. Hoffmann La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, August 14, 2012: US08242247 (9 worldwide citation)

The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.


8

9
Ulrich Brinkmann, Remko Albert Griep, Klaus Kaluza, Anita Kavlie, Christian Klein, Joerg Thomas Regula, Werner Scheuer: Antibodies against human angiopoietin 2. Hoffmann La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, March 13, 2012: US08133979 (6 worldwide citation)

The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.


10
Stefan Hildbrand, Hans Juergen Mair, Roumen Nikolaev Radinov, Yi Ren, James Anderson Wright: Process for the manufacture of pharmaceutically active compounds. Hoffmann La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, December 11, 2012: US08329724 (6 worldwide citation)

According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as novel synthesis routes for key intermediates used in those processes.