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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114064 (54 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase increasing the number of mitotic cycles and mitotic cell division.


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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to inhibit neoplasia. Institute Of Organic Chemistry And Biochemistry A Cademy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114065 (53 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the manufacture of a medicament for inhibiting an enzyme that causes neoplasia in an animal (e.g. a human) and enhancing the processivity of a telomerase.


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Cigler Petr: Solvent system for the preparation of n-alkyl thiophosphoric triamide solutions, composition containing n-alkyl thiophosphoric triamide and the use thereof. Agra Group, Cigler Petr, GABRIELOVA Marta, January 3, 2008: WO/2008/000196 (10 worldwide citation)

Object of the present invention are novel solvent systems for the preparation of N-alkyl thiophosphoric triamide solutions, containing one or more glycol ethers of the general formula (I), wherein R1 is hydrogen or methyl, R2 is selected from the group consisting of C1-C6 alkyl, C3-C6 isoalkyl, C4-C ...


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Krejci Jan, Maly Jan, Stejskalova Radka: Nanostructured working electrode of an electrochemical sensor, method of manufacturing thereof and sensor containing this working electrode. Bvt Technologies, Univerzita Jana Evangelisty Purkyne Prirodovedecka Fakulta, Krejci Jan, Maly Jan, Stejskalova Radka, GABRIELOVA Marta, November 16, 2006: WO/2006/119716 (1 worldwide citation)

A nanostructured working electrode of an electrochemical sensor wherein the working electrode is composed of a material in the form of a film and is inserted onto the sensor. The electrode can be prepared from materials the use of which was impossible in the working electrodes known in the art (e.g. ...


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Svoboda Michal, Svobodova Xenia, Potucek Martin, Kratky Vieroslav, Hanzlik Pavel: Pharmaceutical composition containing taxane derivative destined for the preparation of an infusion solution, method of preparation thereof and use thereof. Iqa, Svoboda Michal, Svobodova Xenia, Potucek Martin, Kratky Vieroslav, Hanzlik Pavel, GABRIELOVA Marta, November 8, 2007: WO/2007/124700 (1 worldwide citation)

A pharmaceutical composition containing a taxane derivative, destined for the preparation of an infusion solution for administration to patients, containing a concentrate consisting of a pharmaceutically effective amount of docetaxel, a suitable solvent, which is preferably ethanol, a surfactant, wh ...


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Hrdina Radim, Burgert Ladislav, Hrdinova Marcela, Androva Jana, Dusek Libor, Dolnik Martin, Loufakis Kyriakos, Koukiotis Christos, Loutsopoulou Eleni, Boutris Kostas, Malliou Nena: Liposome of a textile auxiliary agent, method of its preparation and a preparation containing it. Univerzita Pardubice, Loufakis Chemicals, Clotefi, Hrdina Radim, Burgert Ladislav, Hrdinova Marcela, Androva Jana, Dusek Libor, Dolnik Martin, Loufakis Kyriakos, Koukiotis Christos, Loutsopoulou Eleni, Boutris Kostas, Malliou Nena, GABRIELOVA Marta, July 31, 2008: WO/2008/089707 (1 worldwide citation)

The invention concerns the liposome of textile auxiliary agent consisting of a solid nucleus formed by a textile auxiliary agent and of a membrane formed by a phospholipid and optionally by a surfactant, cholesterol and/or water-soluble polymer of cationic type, wherein the content of the textile au ...


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Holy Antonin, Otmar Miroslav, Piskala Alois: Method of manufacturing 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine. Ustav Organicke Chemie A Biochemie Av Cr Vvi, Holy Antonin, Otmar Miroslav, Piskala Alois, GABRIELOVA Marta, August 28, 2008: WO/2008/101448 (1 worldwide citation)

This invention relates to a method of manufacturing 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-azacytosine by the treatment of protected alkyl or aralkyl 2-deoxy-D-erythro-pentofuranoside with silylated 5-azacytosine in the presence of Lewis acid and subsequent removal the protecting groups.


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Vavrova Katerina, Hrabalek Alexandr, Dolezal Pavel, Holas Tomas: Transdermal penetration enhancers. Univerzita Karlova V Praze Farmaceuticka Fakulta V Hradci Kralové, Vavrova Katerina, Hrabalek Alexandr, Dolezal Pavel, Holas Tomas, GABRIELOVA Marta, September 2, 2004: WO/2004/074235

The invention provides compounds based on ceramide analogues of the general the general formula (I), wherein R1= H or CH2OH; R2 = C8 to C16 alkyl; R3 = C7 to C15 alkyl, cis-heptadec-8­-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 or CH(OH)CH(OH)COOR4; R4 = C7 to C16 alkyl. The compounds of the general formula ...