1
Bennett C Frank, Dean Nicholas M, Kole Ryszard, Kopczynski Casey C: Chimeric oligomeric compounds for modulation of splicing. Isis Pharmaceuticals, Bennett C Frank, Dean Nicholas M, Ercole Biotech, Kole Ryszard, Kopczynski Casey C, FULLER Michael L, March 8, 2007: WO/2007/028065 (65 worldwide citation)

Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulati ...


2
Babcook John S, Kang Jaspal S, Foord Orit, Green Larry, Feng Xiao, Klakamp Scott, Haak Frendscho Mary, Rathanaswami Palaniswami, Pigott Craig, Liang Meina L, Lee Rozanne, Manchulencho Kathy, Faggioni Raffaella, Senaldi Giorgio, Su Qiaojuan Jane: Antibodies directed to tumor necrosis factor and uses thereof. Abgenix, Babcook John S, Kang Jaspal S, Foord Orit, Green Larry, Feng Xiao, Klakamp Scott, Haak Frendscho Mary, Rathanaswami Palaniswami, Pigott Craig, Liang Meina L, Lee Rozanne, Manchulencho Kathy, Faggioni Raffaella, Senaldi Giorgio, Su Qiaojuan Jane, FULLER Michael L, June 17, 2004: WO/2004/050683 (30 worldwide citation)

Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding ...


3
Gudas Jean M, Haak Frendscho Mary, Foord Orit, Liang Meina L, Ahluwalia Kiran, Bhakta Sunil: Antibodies directed to monocyte chemo-attractant protein-1 (mcp-1) and uses thereof. Abgenix, Gudas Jean M, Haak Frendscho Mary, Foord Orit, Liang Meina L, Ahluwalia Kiran, Bhakta Sunil, FULLER Michael L, February 26, 2004: WO/2004/016769 (24 worldwide citation)

Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. ...


4
Landes Gregory M, Haak Frendscho Mary, Chen Ling, Lee Yen Wah Rozanne, Liang Meina L, Feng Xiao, Jia Xiao Chi, Nocerini Mark R: Antibodies directed to phospholipase a2 and uses thereof. Abgenix, Lexicon Genetics Incorporated, Landes Gregory M, Haak Frendscho Mary, Chen Ling, Lee Yen Wah Rozanne, Liang Meina L, Feng Xiao, Jia Xiao Chi, Nocerini Mark R, FULLER Michael L, June 17, 2004: WO/2004/050850 (20 worldwide citation)

The invention described herein relates to antibodies directed to the antigen phospholipase A2 (PLA2) and uses of such antibodies. In particular, in accordance with some embodiments of the invention, there are provided fully human monoclonal antibodies directed to the antigen PLA2. Nucleotide sequenc ...


5
Baker Brenda F, Krainer Adrian R, Hua Yimin: Compositions and methods for modulation of smn2 splicing. Isis Pharmaceuticals, Baker Brenda F, Krainer Adrian R, Hua Yimin, Cold Spring Harbor Laboratory, FULLER Michael L, January 4, 2007: WO/2007/002390 (18 worldwide citation)

Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.


6
ANDERSEN GARY L: Methods and systems for phylogenetic analysis. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Fuller Michael L, December 29, 2010: WO/2010/151842 (12 worldwide citation)

The present invention discloses methods and systems for designing and using organism-specific and/or operational taxon unit (OTU)-specific probes. The methods and systems allow for detecting, identifying and quantitating a plurality of biomolecules or microrganisms in a sample based on the hybridiza ...


7
Owens Samuel M, Carroll Frank I, Abraham Philip, Gunnell Melinda G, Haak Frendscho Mary, Feng Xiao: Antibodies against drugs of abuse. Abgenix, Owens Samuel M, Carroll Frank I, Abraham Philip, Gunnell Melinda G, Haak Frendscho Mary, Feng Xiao, FULLER Michael L, June 17, 2004: WO/2004/050032 (9 worldwide citation)

The present invention is related to antibodies directed to various drugs of abuse and uses of such antibodies. In preferred embodiments, the drugs of abuse are amphetamine, methamphetamine, or phencyclidine (PCP). In particular, in accordance with the present invention, there are provided fully man ...


8
Raeber Olivia, Gazit Bornstein Gadi, Yang Xiaodong, Cartlidge Susan Ann, Tonge David William: Binding proteins specific for insulin-like growth factors and uses thereof. Astrazeneca, Raeber Olivia, Gazit Bornstein Gadi, Yang Xiaodong, Cartlidge Susan Ann, Tonge David William, FULLER Michael L, June 21, 2007: WO/2007/070432 (8 worldwide citation)

Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, an ...


9
PIERCE Niles A, WOLFE Brian R, ZADEH Joseph: Système et procédé de conception de séquences dacides nucléiques, System and method for nucleic acid sequence design. California Institute Of Technology, PIERCE Niles A, WOLFE Brian R, ZADEH Joseph, FULLER Michael L, October 13, 2011: WO/2011/126996 (6 worldwide citation)

Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondary structure is decomposed into a binary tree and candidate mutations are evaluated on leaf nodes of ...


10
Bennett C Frank, Dobie Kenneth W, Freier Susan M, Crooke Stanley T: Compositions and methods for modulation of lmna expression. Isis Pharmaceuticals, Bennett C Frank, Dobie Kenneth W, Freier Susan M, Crooke Stanley T, FULLER Michael L, April 26, 2007: WO/2007/047913 (6 worldwide citation)

Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and ...



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