11
Guillermo P Pardinas: Valveless metering pump with reciprocating, rotating piston. Abbott Laboratories, Frank S Ungemach, Priscilla E Porembski, Daniel W Collins, September 21, 1993: US05246354 (20 worldwide citation)

A valveless metering pump includes a simultaneously reciprocating and rotating piston. The pump head includes radially spaced coplanar ports for drawing and dispensing fluids as the piston rotates sequentially past the ports. The reciprocating stroke of the piston is controlled by adjusting the axis ...


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John J Talley, Daniel P Getman, John N Freskos, Ko Chung Lin, Robert M Heintz, Donald J Rogier Jr, Deborah E Bertenshaw: Retroviral protease inhibitors. Monsanto Company, Frank S Ungemach, Charles E Smith, December 12, 1995: US05475013 (19 worldwide citation)

Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.


14
John J Talley, Daniel P Getman, Gary A DeCrescenzo, Ko Chung Lin, Michael L Vazquez, Richard A Mueller, Kathryn L Reed, Robert M Heintz, Michael Clare, John N Freskos, Eric T Sun: Retroviral protease inhibitors. Frank S Ungemach, January 9, 1996: US05482947 (18 worldwide citation)

Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.


15
John S Ng, Claire A Przybyla, Richard A Mueller, Michael L Vazquez, Daniel P Getman, John J Freskos, Gary A DeCrescenzo, Deborah E Bertenshaw, Robert M Heintz, Suhong Zhang, Chin Liu, Scott A Laneman: Method for making intermediates useful in the synthesis of retroviral protease inhibitors. G D Searle & Co, Frank S Ungemach, July 15, 1997: US05648511 (17 worldwide citation)

A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.


16
Omar S Khalil, Charles F Hanna, Thomas F Zurek: Methods for performing a solid-phase immunoassay. Abbott Laboratories, Frank S Ungemach, Priscilla E Porembski, March 30, 1993: US05198368 (16 worldwide citation)

A method for performing a microparticle diagnostic assay in a device having a shallow sample well for receiving a sample and reagents for forming a reaction mixture, a read well positioned adjacent to said sample well and separated from said sample well by a wall which is constructed and arranged su ...


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Ulrike D Spohr, Michael J Malone, Nathan B Mantlo, Jeffery A Zablocki: Substituted pyrimidinone and pyridone compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, July 16, 2002: US06420385 (15 worldwide citation)

Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and ph ...


19
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Richard V Person, Frank S Ungemach, Steven M Odre, October 1, 2002: US06458813 (13 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ac ...


20
Michael L Vazquez, Richard A Mueller, John J Talley, Daniel Getman, Gary A DeCrescenzo, John N Freskos: Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors. G D Searle & Co, Frank S Ungemach, October 31, 1995: US05463104 (13 worldwide citation)

Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.