1
Guillermo P Pardinas: Pipette tip with self-aligning and self-sealing features. Abbott Laboratories, Frank S Ungemach, August 3, 1993: US05232669 (141 worldwide citation)

A pipette tip for use in automated assay testing systems includes an annular, protruding seal ring on the interior wall of the pipette for engaging a sealing surface on a probe to provide a resilient seal. The pipette tip also includes a positive stop for assuring proper positioning and alignment of ...


2
Emerson W Chan, Werner Schulze, William G Robey, Brian P Braun, Cynthia K Daluga, Andreas A Kapsalis, Kevin M Knigge, John E Stephens, Joseph J Stojak II, David S Vallaris, Benton A Durley deceased, James D Defreese, Carl W Merkh: Multilayer solid phase immunoassay support and method of use. Abbott Laboratories, Priscilla E Porembski, Frank S Ungemach, June 9, 1992: US05120662 (96 worldwide citation)

An immunoassay which is capable of simultaneously detecting any desired number of antigens of one infectious agent, or combinations of antigens of several infectious agents, or any desired number of immunoglobulins of one infectious agent, or combinations of immunoglobulins of several infectious age ...


3
Carl W Merkh, James D Defreese, Benton A Durley III deceased: Test array for performing assays. Abbott Laboratories, Lawrence S Pope, Frank S Ungemach, January 25, 1994: US05281540 (75 worldwide citation)

A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immunoassays for human IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel is provided to position and hold a ...


4
Omar S Khalil, Charles F Hanna, Denise G Huff, Thomas F Zurek: Device for performing solid-phase diagnostic assay. Abbott Laboratories, Frank S Ungemach, Priscilla E Porembski, Daniel W Collins, September 14, 1993: US05244630 (66 worldwide citation)

A disposable device suitable for performing automated solid-phase diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detached by o ...


5
Tzyy Wen Jeng, Kristin D Elmore, Gary M Oosta, Terry A Pry: Devices and methods for the collection of a predetermined volume of plasma or serum. Abbott Laboratories, Frank S Ungemach, Daniel R Curry, November 12, 1991: US05064541 (50 worldwide citation)

A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole b ...


6
Samar K Kundu, Richard W George, Steven C March, Sangvorn Rutnarak: Breath component monitoring device. Abbott Laboratories, Frank S Ungemach, Jeffrey Sharp, December 29, 1992: US05174959 (40 worldwide citation)

The present invention relates to methods and materials for the detection of ketone and aldehyde analytes in fluid samples by means of reacting analyte containing samples with a first solid matrix material to which a nitroprusside salt is coupled and a second solid matrix material to which an amine i ...


7
Samar K Kundu, Richard W George, Steven C March, Sangvorn Rutnarak: Method and device for ketone measurement. Abbott Laboratories, Frank S Ungemach, Jeffrey S Sharp, December 10, 1991: US05071769 (39 worldwide citation)

Methods and materials detect ketone and aldehyde analytes in fluid samples by reacting analyte containing samples with a first solid matrix material to which a nitroprusside salt is coupled and a second solid matrix material to which an amine is covalently coupled. Methods and devices are also provi ...


8
Michael L Vazquez, Richard A Mueller, John J Talley, Daniel Getman, Gary A DeCrescenzo, John N Freskos: Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors. G D Searle & Co, Frank S Ungemach, May 28, 1996: US05521219 (26 worldwide citation)

Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.


9
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, December 25, 2001: US06333341 (22 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ac ...


10
Ulrike D Spohr, Michael J Malone, Nathan B Mantlo: Substituted pyrimidine compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, June 25, 2002: US06410729 (21 worldwide citation)

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ...