1
Donna R Cody, Sheila H H DeWitt, John C Hodges, John S Kiely, Walter H Moos, Michael R Pavia, Bruce D Roth, Mel C Schroeder, Charles J Stankovic: Apparatus for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer III, Francis J Tinney, June 28, 1994: US05324483 (194 worldwide citation)

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav ...


2
Alexander James Bridges, William Alexander Denny, David Fry, Alan Kraker, Robert Frederick Meyer, Gordon William Rewcastle, Andrew Mark Thompson: Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family. Warner Lambert Company, Francis J Tinney, August 5, 1997: US05654307 (131 worldwide citation)

Novel 4-substituted amino pyrido pyrimidine and 4-substituted amino pyrido pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinase are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovi ...


3
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, March 26, 1991: US05003080 (104 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-( ...


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Donald E Butler, Tung V Le, Thomas N Nanninga: Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, March 29, 1994: US05298627 (80 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where .alpha.-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4 ...


6
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, March 17, 1992: US05097045 (76 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-( ...


7
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, June 23, 1992: US05124482 (73 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans(.+-.)-5-(4 ...


8
Donald E Butler, Tung V Le, Thomas N Nanninga: Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, August 30, 1994: US05342952 (70 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where .alpha.-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4 ...


9
Donald E Butler, Tung V Le, Alan Millar, Thomas N Nanninga: Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate. Warner Lambert Company, Francis J Tinney, October 13, 1992: US05155251 (68 worldwide citation)

An improved process for the preparation of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate is described where a halo hydroxyester or other activated dihydroxyester is converted in two steps to the desired product.


10
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, September 22, 1992: US05149837 (66 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-( ...