1
Braydon Charles Guild, Michael Heartlein: mRNA for use in treatment of human genetic diseases. Shire Human Genetic Therapies, Choate Hall & Stewart, Fangli Chen, October 7, 2014: US08853377 (35 worldwide citation)

Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification conferring stability to the RNA, as well as related methods, are disclosed.


2
Roy Rabindranauth Sooknanan, Gilles Bernard Tremblay, Mario Filion: Polynucleotides and polypeptide sequences involved in the process of bone remodeling. Alethia Biotherapeutics, Fangli Chen, Choate Hall & Stewart, August 2, 2011: US07989160 (19 worldwide citation)

This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and com ...


3
Jonathan H LeBowitz, Stephen M Beverley, William S Sly: Targeted therapeutic proteins. Zystor Therapeutics, Choate Hall & Stewart, Fangli Chen, December 8, 2009: US07629309 (12 worldwide citation)

Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the target ...


4
Anthony P Shuber: Methods for disease detection. Genzyme Corporation, Choate Hall & Stewart, Fangli Chen, October 12, 2010: US07811757 (11 worldwide citation)

The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.


5
Roy Rabindranauth Sooknanan, Gilles Bernard Tremblay, Mario Filion: Antibodies that bind polypeptides involved in the process of bone remodeling. Alethia Biotherapeutics, Fangli Chen, Robert N Sahr, Choate Hall & Stewart, September 24, 2013: US08540988 (10 worldwide citation)

This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and com ...


6
Roy Rabindranauth Sooknanan, Gilles Bernard Tremblay, Mario Filion: Methods of impairing osteoclast differentiation using antibodies that bind siglec-15. Alethia Biotherapeutics, Choate Hall & Stewart, Fangli Chen, Robert N Sahr, May 1, 2012: US08168181 (10 worldwide citation)

This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding polypeptides; uses of the polynucleotides, polypeptides, variants and derivatives; and methods and com ...


7
Roy Rabindranauth Sooknanan, Gilles Bernard Tremblay, Mario Filion: Antibodies that bind polypeptides involved in the process of bone remodeling. Alethia Biotherapeutics, Choate Hall & Stewart, Fangli Chen, Robert N Sahr, April 30, 2013: US08431126 (9 worldwide citation)

This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding polypeptides; uses of the polynucleotides, polypeptides, variants and derivatives; and methods and com ...


8
Kurt von Figura, Bernhard Schmidt, Thomas Dierks, Michael W Heartlein, Maria Pia Cosma, Andrea Ballabio: Cell that expresses a sulfatase and a formylglycine generating enzyme. Shire Human Genetic Therapies, Choate Hall & Stewart, Fangli Chen, July 24, 2012: US08227212 (9 worldwide citation)

This invention relates to methods and compositions for the diagnosis and treatment of Multiple Sulfatase Deficiency (MSD) as well as other sulfatase deficiencies. More specifically, the invention relates to isolated molecules that modulate post-translational modifications on sulfatases. Such modific ...


9
Jonathan LeBowitz, John Maga: Acid alpha-glucosidase and fragments thereof. ZyStor Therapeutics, Choate Hall & Stewart, Fangli Chen, August 31, 2010: US07785856 (8 worldwide citation)

Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic ...


10
Jonathan H LeBowitz, Stephen M Beverley: Method for targeting lysosomal enzymes. ZyStor Therapeutics, Choate Hall & Stewart, Fangli Chen, December 28, 2010: US07858576 (8 worldwide citation)

Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the target ...