1
Tse Wen Chang, Liming Yu: Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide. Tanox Biosystems, Eric P Mirabel, March 3, 1998: US05723125 (108 worldwide citation)

Disclosed is a hybrid recombinant protein consisting of human interferon, preferably interferon-.alpha. (IFN.alpha.), and human immunoglobulin Fc fragment, preferably .gamma.4 chain, joined by a peptide linker comprising the sequence Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser (S ...


2
Tse Wen Chang, Liming Yu: Hybrid with interferon-.beta. and an immunoglobulin Fc joined by a peptide linker. Tanox, Eric P Mirabel, June 1, 1999: US05908626 (84 worldwide citation)

Disclosed is a hybrid recombinant protein consisting of human interferon-.beta., and a human immunoglobulin Fc fragment, preferably .gamma.4 chain, joined by a peptide linker comprising the sequence Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser (SEQ ID NO:1).


3
Ronald L Young: Antiestrogens and their use in treatment of menopause and osteoporosis. BCM Technologies, Eric P Mirabel, Ned L Conley, David A Rose, January 16, 1990: US04894373 (73 worldwide citation)

Disclosed is a method for treating menopausal symptoms and treating and preventing osteoporosis, wherein a true antiestrogen is administered and estrogen is not. This treatment is effective for female osteoporosis and can also be used to treat male osteoporosis. Examples of true antiestrogens are cl ...


4
Michael Seul, Alice X Li: Array cytometry. Bioarray Solutions, Eric P Mirabel, Julie Bowker, October 25, 2005: US06958245 (70 worldwide citation)

A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on the combination of three functional ...


5
Tse Wen Chang: Antigenic epitopes of IgE present on B cell but not basophil surface. Tanox Biosystems, Eric P Mirabel, Giulio A DeConti, February 25, 1992: US05091313 (67 worldwide citation)

Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. The epitope can be exploited for diagnosis.


6
Ghazala Hashmi, Michael Seul, Joachim Messing: Genetic analysis and authentication. Bioarray Solutions, Eric P Mirabel, January 2, 2007: US07157228 (63 worldwide citation)

This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), ...


7
Xiongwu Xia, Michael Seul, Chiu Chau, Scott Determan: Analysis, secure access to, and transmission of array images. BioArray Solutions, Eric P Mirabel, April 28, 2009: US07526114 (55 worldwide citation)

Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a ...


8
Sukanta Banerjee, Cecilia Georgescu, Eric S Daniels, Victoria L Dimonie, Michael Seul: Production of dyed polymer microparticles. Bioarray Solutions, Eric P Mirabel, Daniel Monaco, November 15, 2005: US06964747 (52 worldwide citation)

A dye, such as a fluorescent dye, is incorporated into polymer microparticles using a solvent system composed of a first solvent in which the dye and the microparticle polymer are soluble, a second solvent in which the dye and the microparticle polymer are not or only weakly soluble, and a third sol ...


9
Michael Seul, Sukanta Banerjee, Kairali Podual: On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces. Eric P Mirabel, March 16, 2004: US06706163 (46 worldwide citation)

A method and apparatus for fractionation of a mixture of particles and for particle analysis are provided, in which LEAPS (“Light-controlled Electrokinetic Assembly of Particles near Surfaces”) is used to fractionate and analyze a plurality of particles suspended in an interface between an electrode ...


10
Michael Seul, Richard H Ebright: Color-encoding and in-situ interrogation of matrix-coupled chemical compounds. BioArray Solutions, Eric P Mirabel, Daniel A Monaco, August 1, 2006: US07083914 (45 worldwide citation)

A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in a ...



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