1
John S Kent, Danny H Lewis, Lynda M Sanders, Thomas R Tice: Microencapsulation of water soluble active polypeptides. Syntex, Ellen J Wise, Tom M Moran, Alan Krubiner, June 23, 1987: US04675189 (324 worldwide citation)

This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.


2
John J Nestor Jr, Brian H Vickery: Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists. Syntex, Ellen J Wise, Tom M Moran, Alen M Krubiner, May 19, 1987: US04667014 (54 worldwide citation)

Synthetic nonpeptide and decapeptide LHRH antagonist analogs have a novel guanido-substituted, amidine, tertiary or quaternary amine water-soluble aminoacyl residue at position 6.


3
Charles H Hsiao, John S Kent: Controlled release naproxen and naproxen sodium tablets. Syntex, Ellen J Wise, Tom M Moran, Alan M Krubiner, February 7, 1989: US04803079 (41 worldwide citation)

A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet comprising a homogeneous matrix comprising about 4-9 weight percent of hydroxypropyl methylcellulose having a number average molecular weight in the range of from about 80, ...


4
Peter H Nelson, Anthony C Allison, Elsie M Eugui: Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis. Syntex, Ellen J Wise, Tom M Moran, Alan M Krubiner, August 11, 1987: US04686234 (20 worldwide citation)

Compounds useful for treating inflammatory diseases, in particular rheumatoid arthritis, represented by the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein:


5
Peter H Nelson, Anthony C Allison, Elsie M Eugui, Joseph M Muchowski: Mycophenolic acid derivatives in the treatment of rheumatoid arthritis. Syntex, Ellen J Wise, Tom M Moran, February 16, 1988: US04725622 (19 worldwide citation)

A method of treating rheumatoid arthritis which method comprises administering to a mammal in need of such treatment a therapeutically effective amount of a compound of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein:


6

7
Alexander Krantz, Robin Spencer, Tim Tam, Teng J Liak: 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use. Syntex, Tom M Moran, Liza K Toth, Ellen J Wise, May 12, 1987: US04665070 (7 worldwide citation)

2-Oxy-4H-3,1-benzoxazin-4-ones represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 0-4;


8
Robin D Clark: Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as .alpha..sub.2 -blockers. Syntex, Brian Lewis, Ellen J Wise, Tom M Moran, December 13, 1988: US04791108 (6 worldwide citation)

Compounds of formulas (1) and (2): ##STR1## in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenendioxy or ethylene-1,2-dioxy, and


9
Arthur F Kluge, Anthony L Willis, Counde O Yang: Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties. Syntex, Ellen J Wise, Tom M Moran, Alan M Krubiner, August 26, 1986: US04608388 (6 worldwide citation)

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): ##STR1## wherein: n is 2 or 3;


10
Helen Y Wu, Walter Kurz: Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties. Syntex, Ellen J Wise, Tom M Moran, Brian Lewis, April 5, 1988: US04735966 (6 worldwide citation)

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): ##STR1## wherein: A is --C.tbd.C--, trans --HC.dbd.CH--, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CHCH.sub.2 --;



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