1
John S Kent: Cholesterol matrix delivery system for sustained release of macromolecules. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, June 5, 1984: US04452775 (221 worldwide citation)

Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The cholesteric matrix comprises cholesterol powder and ...


2
Charles H Hsiao, John S Kent: Controlled release naproxen and naproxen sodium tablets. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, February 18, 1986: US04571333 (39 worldwide citation)

A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet being a homogeneous matrix comprising about 4-9 weight percent of hydroxypropylmethylcellulose having a number average molecular weight in the range of from about 80,000 to ...


3
M Rene Malinow: Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis. Medical Research Foundation of Oregon, Ellen J Buckles, Tom M Moran, Alan M Krubiner, July 22, 1986: US04602005 (37 worldwide citation)

This invention discloses novel glycosides which are potent inhibitors of cholesterol absorption and therefore useful in treating hypercholesterolemia and atherosclerosis. Particularly useful in this respect is glycoside tigogenin cellobioside. The method of use for treatment of hypercholesterolemia ...


4
Gene A Spiller: Cellulose/carboxymethyl cellulose mixtures useful for controlling fecal output, and methods employing them. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, April 24, 1984: US04444761 (13 worldwide citation)

Methods of controlling fecal output and of appetite control, and compositions therefor, employing a fiber-containing mixture of cellulose with CMC, are described.


5
John J Nestor, Brian H Vickery: Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, April 8, 1986: US04581169 (10 worldwide citation)

Synthetic nona-peptide and deca-peptide LHRH antagonist analogs have a novel guanido-substituted, amidine, tertiary or quaternary aminoacyl residue at position 6.


6
Joseph M Muchowski, Robert Greenhouse: 5-Benzoyl-7-halo-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1,1-dicarboxylic acids and esters thereof. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, June 26, 1984: US04456759 (5 worldwide citation)

5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids, represented by the formula ##STR1## and the pharmaceutically acceptable non-toxic esters and salts thereof, wherein:


7
Joseph M Muchowski, Stefan H Unger: 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, December 24, 1985: US04560699 (5 worldwide citation)

Novel 5-(4-vinyl- or 4-ethynylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids represented by the formula ##STR1## and the pharmaceutically acceptable, non-toxic alkyl esters and salts thereof, wherein R is vinyl or ethynyl, and Y is hydrogen, a lower alkyl group having from 1 to 6 c ...


8
Joseph M Muchowski, Robert Greenhouse, Jack Ackrell, Tsung Tee Li, Jurg R Pfister: .+-.2-[Phenethyl]-5-[(3,4-methylenedioxy)-.alpha.-hydroxybenzyl]py rrolidine antihypertensives and use thereas. Ellen J Buckles, Tom M Moran, Alan M Krubiner, September 24, 1985: US04543361 (5 worldwide citation)

A compound of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof are potent antihypertensive agents and are therefore useful as cardiovascular system regulators.


9
Joseph M Muchowski, Robert Greenhouse: 5-Aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-decarboxylates. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, July 3, 1984: US04458081 (5 worldwide citation)

5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula ##STR1## wherein: X is hydrogen or lower alkyl; Ar is a moiety selected from the group consisting of ##STR2## in which: Y is oxygen or sulfur;


10
L David Waterbury: Treatment and prevention of ocular hypertension. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, December 10, 1985: US04558066 (3 worldwide citation)

This invention relates to a method of treatment of ocular hypertension and to a topical ophthalmic pharmaceutical composition useful for management of ocular hypertension.