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Martin P Kunstmann, Irwin J Hollander, Philip Hamann, Arthur Kunz: Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates. American Cyanamid Company, Elizabeth M Barnhard, February 3, 1998: US05714586 (150 worldwide citation)

A method is provided for preparing monomeric calicheamicin derivative/carrier conjugates with higher drug loading/yield and decreased aggregation. These conjugates are prepared by incubating a calicheamicin derivative and a proteinaceous carrier in a solution comprising a non-nucleophilic, protein-c ...


2
Philip Ross Hamann, Lois Hinman, Irwin Hollander, Ryan Holcomb, William Hallett, Hwei Ru Tsou, Martin J Weiss: Conjugates of methyltrithio antitumor agents and intermediates for their synthesis. American Cyanamid Company, Elizabeth M Barnhard, H G Jackson, June 30, 1998: US05773001 (142 worldwide citation)

This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, o ...


3
Philip Ross Hamann, Lois Hinman, Irwin Hollander, Ryan Holcomb, William Hallett, Hwei Ru Tsou, Martin J Weiss: Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents. American Cyanamid Company, Elizabeth M Barnhard, H Gerald Jackson, April 14, 1998: US05739116 (94 worldwide citation)

This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, o ...


4
Philip Ross Hamann, Lois Hinman, Irwin Hollander, Ryan Holcomb, William Hallett, Hwei Ru Tsou, Martin J Weiss: Process for preparing conjugates of methyltrithio antitumor agents. American Cyanamid Company, Elizabeth M Barnhard, H G Jackson, March 2, 1999: US05877296 (93 worldwide citation)

This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, o ...


5
Catia Bastioli, Vittorio Bellotti, Luciano Del Guidice, Roberto Lombi: Polymer compositions for the production of articles of biodegradable plastics material and methods of their preparation. Novamont S p A, Elizabeth M Barnhard, Bryan Cave, November 2, 1993: US05258430 (87 worldwide citation)

Polymer compositions useful for the production of articles of biodegradable plastics material with improved biodegradability include destructed starch and a polymer selected from the group consisting of ethylene-vinyl alcohol, polyvinyl alcohol and mixtures thereof wherein at least a portion of the ...


6
Philip Ross Hamann, Lois Hinman, Irwin Hollander, Ryan Holcomb, William Hallett, Hwei Ru Tsou, Martin J Weiss: Linkers useful for the synthesis of conjugates of methyltrithio antitumor agents. American Cyanamid Company, Elizabeth M Barnhard, H G Jackson, June 16, 1998: US05767285 (86 worldwide citation)

This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, o ...


7
Catia Bastioli, Vittorio Bellotti, Luciano del Giudice, Gianfranco del Tredici, Roberto Lombi, Angelos Rallis: Biodegradable articles based on starch and process for producing them. Novamont S p A, Elizabeth M Barnhard, November 16, 1993: US05262458 (78 worldwide citation)

Formed articles comprising destructurized starch, an ethylene-acrylic acid copolymer and a product of the interaction of starch and ethylene-acrylic acid copolymer wherein the starch not bound to the copolymer is in the form of particles having sizes below 1 micron. The water content of such article ...


8
Gerard Marx: Methods for tissue embedding and tissue culturing. New York Blood Center, Elizabeth M Barnhard, Bryan Cave, May 2, 1995: US05411885 (76 worldwide citation)

Methods of embedding and culturing tissue employing a fibrin glue composition of 2 to 100 mg/ml fibrinogen, 1 to 200 U/ml fibrinogen-activating enzyme, and 1 to 30 mM Ca(II) compound, are disclosed.


9
Jeffrey Askanazi, David P Katz, Tuula Manner: Methods and compositions for treating acute or chronic pain and drug addiction. Aminotek Sciences, Elizabeth M Barnhard, October 26, 1993: US05256669 (69 worldwide citation)

Methods and compositions for treating acute or chronic pain in a mammal comprising administering a therapeutically effective amount of an analgesic solution comprising at least one branched chain amino acid selected from the group consisting of leucine, isoleucine, and valine, or administering a the ...


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