1
Richard Cortese, Felix Theeuwes: Osmotic device with hydrogel driving member. ALZA Corporation, Paul L Sabatine, Edward L Mandell, May 4, 1982: US04327725 (922 worldwide citation)

An osmotic device is disclosed comprising a semipermeable wall surrounding a compartment housing an agent that is insoluble to very soluble in aqueous and biological fluids, and a layer of a fluid swellable, hydrogel. A passageway in the wall connects the agent with the exterior of the device.


2
Felix Theeuwes, Atul D Ayer: Osmotic system having laminar arrangement for programming delivery of active agent. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, February 22, 1977: US04008719 (623 worldwide citation)

An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a la ...


3
Felix Theeuwes: Microporous-semipermeable laminated osmotic system. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, March 17, 1981: US04256108 (442 worldwide citation)

An osmotic therapeutic system for delivering a drug is disclosed. The system comprises a drug delivery module which module comprises a rate controlling laminated wall surrounding a reservoir and has a portal for delivering drug from the system. The laminated wall comprises a semipermeable lamina in ...


4
Felix Theeuwes, Richard J Saunders, Wayne S Mefford: Process for forming outlet passageways in pills using a laser. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, May 9, 1978: US04088864 (416 worldwide citation)

A high speed process and apparatus are disclosed for forming outlet passageways of accurate, predetermined size in the walls of pills which dispense their contents by osmotically pumping said contents out said outlet passageways. The pills are moved in succession by an indexer past a passageway form ...


5
Pieter Bonsen, Patrick S Wong, Felix Theeuwes: Method of delivering drug with aid of effervescent activity generated in environment of use. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, May 5, 1981: US04265874 (407 worldwide citation)

A method is disclosed for delivering a drug substantially free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment, housing (1) a drug that exhibits limited solubility under neutral and acid conditions; and (2) a compound capable ...


6
Atul D Ayer, Felix Theeuwes: Osmotic system with distribution zone for dispensing beneficial agent. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, April 29, 1980: US04200098 (406 worldwide citation)

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned ...


7
Atul D Ayer, Felix Theeuwes: Process for manufacturing device with dispersion zone. Alza Corporation, Paul L Sabatine, Edward L Mandell, August 25, 1981: US04285987 (373 worldwide citation)

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned ...


8
Alejandro Zaffaroni: Novel drug delivery device. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, April 6, 1976: US03948254 (331 worldwide citation)

A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to th ...


9
Alejandro Zaffaroni: Microporous drug delivery device. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, November 23, 1976: US03993072 (323 worldwide citation)

A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to th ...


10
Patrick S L Wong, Brian Barclay, Joseph C Deters, Felix Theeuwes: Osmotic device with dual thermodynamic activity. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, September 16, 1986: US04612008 (321 worldwide citation)

An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects t ...



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