1
Jason P Schrum, Noubar B Afeyan, Gregory J Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M Elbashir: Engineered nucleic acids encoding a modified erythropoietin and their expression. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, April 29, 2014: US08710200 (40 worldwide citation)

Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.


2
Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: Modified polynucleotides for the production of G-CSF. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, March 25, 2014: US08680069 (38 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


3
Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: Method for producing a protein of interest in a primate. Moderna Therapeutics, DT Ward P C, Jennifer F Bryan, March 4, 2014: US08664194 (26 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


4
Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides. Moderna Therapeutics, DT Ward P C, Jennifer F Bryan, June 17, 2014: US08754062 (24 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


5
Tirtha Chakraborty, Antonin de Fougerolles: Modified polynucleotides encoding aquaporin-5. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, December 29, 2015: US09220792 (7 worldwide citation)

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and modified mRNA (mmRNA) molecules.


6
Tirtha Chakraborty, Antonin de Fougerolles: Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders. Moderna Therapeutics, DT Ward P C, Donna T Ward J D, Jennifer F Bryan J D, January 12, 2016: US09233141 (7 worldwide citation)

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.


7
Tirtha Chakraborty, Antonin de Fougerolles: Modified polynucleotides for the production of secreted proteins. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, November 24, 2015: US09192651 (7 worldwide citation)

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.


8
Tirtha Chakraborty, Antonin de Fougerolles: Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders. Moderna Therapeutics, DT Ward P C, Donna T Ward J D, Jennifer F Bryan J D, December 29, 2015: US09220755 (7 worldwide citation)

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.


9
Susanne Wieland, Karl Heinz Maurer, Beatrix Kottwitz, Frank Niehaus, Patrick Lorenz: Alkaline proteases and detergents and cleaners comprising these alkaline proteases. B R A I N Biotechnology Research and Information Network, DT Ward P C, July 26, 2011: US07985570 (2 worldwide citation)

The present application relates to two novel proteases (SEQ ID NO: 4 and 7) which are similar to one another. The DNA of the two proteases, was obtained from soil samples, and C-terminally deleted, producing proteolytically active fragments thereof (SEQ ID NO: 5 and 8). The invention also provides a ...


10
Tirtha Chakraborty, Antonin de Fougerolles: Modified polynucleotides encoding septin-4. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, October 6, 2015: US09149506 (1 worldwide citation)

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.