1
Mahesh V Patel, Feng Jing Chen: Solid carriers for improved delivery of active ingredients in pharmaceutical compositions. Lipocine, Dianne E Reed, Reed & Associates, June 19, 2001: US06248363 (550 worldwide citation)

The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a ...


2
Victor E Kimball, Laurie E Lynch, Irvin T Pierskalla, Christopher H Porter: In situ calibration system for sensors located in a physiologic line. Optical Sensors Incorporated, Dianne E Reed & Associates Reed, November 2, 1999: US05976085 (404 worldwide citation)

A method is provided for calibrating sensors used to analyze characteristics of physiologic fluids such as blood. The method involves the use of a sensor assembly having an analyte-responsive sensor in communication with a passageway which is in divertable fluid communication with a physiologic line ...


3
Mahesh V Patel, Feng Jing Chen: Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents. Lipocine, Dianne E Reed, Reed & Associates, September 25, 2001: US06294192 (363 worldwide citation)

The present invention relates to triglyceride-free pharmaceutical compositions for delivery of hydrophobic therapeutic agents. Compositions of the present invention include a hydrophobic therapeutic agent and a carrier, where the carrier is formed from a combination of a hydrophilic surfactant and a ...


4
Feng Jing Chen, Mahesh V Patel: Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents. Lipocine, Dianne E Reed, Reed & Associates, May 7, 2002: US06383471 (349 worldwide citation)

The present invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier. The carrier includes an ionizing agent capable of ionizing the functional group, a surfactant, and optionally solubilizers, trigl ...


5
Mahesh V Patel, Feng Jing Chen: Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions. Lipocine, Dianne E Reed, Reed & Eberle, May 27, 2003: US06569463 (317 worldwide citation)

The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a ...


6
Michael S Urdea, Thomas Horn: Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use. Chiron Corporation, Dianne E Reed, Kenneth M Goldman, Robert P Blackburn, January 28, 1997: US05597909 (271 worldwide citation)

Methods and reagents are provided for synthesizing polynucleotides containing modified deoxyribose residues. Monomeric reagents having the structural formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein, are used to create polynucleotides having nonnucleo ...


7
Feng Jing Chen, Mahesh V Patel: Clear oil-containing pharmaceutical compositions. Lipocine, Dianne E Reed, Reed & Associates, July 31, 2001: US06267985 (264 worldwide citation)

The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a triglyceride and a carrier, where the carrier is formed from a combination of at least tw ...


8
Donald G Wallace, Gregory M Cruise, Woonza M Rhee, Jacqueline Anne Schroeder, George T Coker III, Marcee M Maroney: Rapid gelling biocompatible polymer composition. Cohesion Technologies, Dianne E Reed, Laurie A Axord, November 6, 2001: US06312725 (217 worldwide citation)

This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, ...


9
Michael S Urdea: Polynucleotide determination with selectable cleavage sites. Chiron Corporation, Dianne E Reed, June 2, 1992: US05118605 (198 worldwide citation)

Novel methods for assaying a nucleic acid analyte are provided, which employ polynucleotides having oligonucleotide sequences substantially homologous to a sequence of interest in the analyte, where the presence or absence of hybridization at a predetermined stringency provides for the release of a ...


10
Michael S Urdea, Thomas Horn: Photolabile reagents for incorporation into oligonucleotide chains. Chiron Corporation, Dianne E Reed, Kenneth M Goldman, Robert P Blackburn, November 2, 1993: US05258506 (182 worldwide citation)

Novel photolabile photochemical reagents are disclosed. The reagents are useful in a variety of biochemical and chemical contexts, including nucleic hybridization assays and chemical phosphorylation of hydroxyl-containing compounds. The reagents are particularly useful for introducing cleavable site ...