1
Eugene P Goldberg, Ali Yahiaoui, Khalid Mentak, Theresa Rivero Erickson, James Seeger: Biofunctional surface modified ocular implants, surgical instruments, medical devices, prostheses, contact lenses and the like. University of Florida, Dennis P Clarke, Miles & Stockbridge, May 14, 2002: US06387379 (294 worldwide citation)

A method for modifying the surface of a material adapted for contact with tissue of a human or non-human animal to impart biofunctional, bioactive or biomimetic properties to the surface comprising:


2
Frank J Bova, William A Friedman: Repeat fixation for frameless stereotactic procedure. University of Florida Research Foundation, Dennis P Clarke, Kerkam Stowell Kondracki & Clarke, December 31, 1996: US05588430 (213 worldwide citation)

Repeat fixation for medical procedures is accomplished using a non-invasive locator, specifically a bite plate. The bite plate has at least three fiducial markers on it. The fiducial markers may be LEDs, radiopaque markers for angiography or computerized tomography (CT) imaging or magnetic resonance ...


3
Robert R Brownlee: Method and apparatus for the suppression of far-field interference signals for implantable device data transmission systems. Cardiac Control Systems, Dennis P Clarke, Kerkam Stowell Kondracki & Clarke, May 20, 1997: US05630835 (210 worldwide citation)

An electronic device for non-invasively communicating with an implanted device, such as, for example, a cardiac pacemaker. The electronic programming device includes a transceiver having an antenna, a transmitter portion and a receiver portion. The antenna portion is arranged to have two coils arran ...


4
Frank J Bova, William A Friedman: Computer controlled guidance of a biopsy needle. University of Florida, Dennis P Clarke, Miles & Stockbridge, April 8, 2003: US06546279 (182 worldwide citation)

A computer controlled system for guiding the needle device, such as a biopsy needle, by reference to a single mode medical imaging system employing any one of computed tomography imaging (CTI) equipment, magnetic resonance imaging equipment (MRI), fluoroscopic imaging equipment, or 3D ultrasound sys ...


5
Frank J Bova, William A Friedman: Marker system and related stereotactic procedure. University of Florida Research Foundation, Dennis P Clarke, Kerkam Stowell Kondracki & Clarke, September 21, 1999: US05954647 (164 worldwide citation)

Repeat fixation for medical procedures is accomplished using a non-invasive locator, specifically a bite plate. The bite plate has at least three fiducial markers on it. The fiducial markers may be LEDs, radiopaque markers for angiography or computerized tomography (CT) imaging or magnetic resonance ...


6
Harold Alexander, John R Parsons, Irving D Strauchler, Andrew B Weiss: Bio-absorbable composite tissue scaffold. University of Medicine and Dentistry of New Jersey, Dennis P Clarke, April 23, 1985: US04512038 (162 worldwide citation)

The invention comprises a bio-compatible composition suitable for constructing surgical articles for the repair or replacement of a part of the body of a human or non-human animal, e.g., ligaments, tendons, bones, comprising a composite of a bio-absorbable polymer and at least one substrate of a plu ...


7
Eugene P Goldberg, William E Longo, Hiroo Iwata: Microspheres for incorporation of therapeutic substances and methods of preparation thereof. University of Florida, Dennis P Clarke, June 9, 1987: US04671954 (147 worldwide citation)

Novel hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide in an organic solvent solution of a high molecular weight polymer to form a stabilized dispersion of microspheres and cross-linking said microspheres with a polyfu ...


8
Robert R Brownlee: Single preformed catheter configuration for a dual-chamber pacemaker system. Cardiac Control Systems, Dennis P Clarke, Kerkam Stowell Kondracki & Clarke, June 30, 1998: US05772693 (142 worldwide citation)

A single preformed catheter configuration for a dual-chamber pacemaker system is provided. The catheter is formed of a heat-settable biocompatible material such as, for example, polyether polyurethane, and is formed in a predetermined shape to enhance and stabilize atrial electrode contact on the in ...


9
George S Abela: Laser method and apparatus for the recanalization of vessels and the treatment of other cardiac conditions. University of Florida, Dennis P Clarke, August 29, 1989: US04860743 (136 worldwide citation)

Cardiac conditions such as blockages in arteries caused by plaque build-up are treated intravascularly with laser radiation using an optical fiber having a heat conducting end cap on its distal end. A spherical lens within the end cap focuses a small portion of the laser energy directly into the pla ...


10
Frank M Bova, William A Friedman, Sanford L Meeks, John M Buatti: Ultrasonic guidance of target structures for medical procedures. Dennis P Clarke, Miles & Stockbridge, May 21, 2002: US06390982 (130 worldwide citation)

A system comprising a combination of an ultrasound probe and both passive and active infrared tracking systems. The combined system enables a real time image display of the entire region of interest without probe movement; real time tracking of the target region permitting physiological gating; and ...



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