1
Lance E Steward, George Sachs, Kei Roger Aoki: Methods and compositions for the treatment of pancreatitis. Allergan, Dean G Stathakis, Carlos A Fisher, Martin A Voet, January 18, 2005: US06843998 (68 worldwide citation)

Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent accumulation of digestive enzymes within the pancreas.


2
J Oliver Dolly, Yan Li, Kuo Chion Chan: Activatable recombinant neurotoxins. Allergan, Dean G Stathakis, Martin A Voet, Joel B German, November 7, 2006: US07132259 (61 worldwide citation)

The invention provides, in part, compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also provides, in part, nucleic acid molecules encoding such polypeptides, and methods of making such polypeptides and nucleic acid molecules.


3
Ester Fernandez Salas, Lance E Steward, Kei Roger Aoki: Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins. Allergan, Dean G Stathakis, Joel B German, Martin A Voet, February 27, 2007: US07183066 (53 worldwide citation)

The present invention provides a method of determining clostridial toxin activity by (a) contacting with a sample a cell containing a clostridial toxin substrate that includes a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; a ...


4
J Oliver Dolly, Yan Li, Kuo Chion Chan: Activatable recombinant neurotoxins. Allergan, Dean G Stathakis, Joel B German, Martin A Voet, September 2, 2008: US07419676 (49 worldwide citation)

Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.


5
Lance E Steward, Ester Fernandez Salas, Kei Roger Aoki: Fret protease assays for botulinum serotype A/E toxins. Allergan, Dean G Stathakis, Joel B German, Martin A Voet, April 24, 2007: US07208285 (49 worldwide citation)

The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an ...


6
Lance E Steward, Ester Fernandez Salas, Kei Roger Aoki: Fret protease assays for clostridial toxins. Allergan, Dean G Stathakis, Joel B German, Martin A Voet, February 19, 2008: US07332567 (40 worldwide citation)

The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an ...


7
J Oliver Dolly, Yan Li, Kuo Chion Chan: Activatable recombinant neurotoxins. Allergan, Dean G Stathakis, Joel B German, Martin A Voet, September 9, 2008: US07422877 (39 worldwide citation)

Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.


8
Stephen Donovan: Clostridial toxin derivatives and methods for treating pain. Allergan, Dean G Stathakis, Joel B German, Martin A Voet, July 17, 2007: US07244437 (39 worldwide citation)

Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety ...


9
Lance E Steward, Fernandez Salas Ester, Joseph Francis, Shengwin Li, Marcella A Gilmore, Kei Roger Aoki: Multivalent Clostridial toxin derivatives and methods of their use. Allergan, Dean G Stathakis, Joel B German, Martin A Voet, April 7, 2009: US07514088 (38 worldwide citation)

The present invention is directed to multivalent Clostridial neurotoxin derivatives having more than one binding domain directed to a cell surface feature of a target cell. Such modified neurotoxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Condit ...


10
Stephen Donovan: Botulinum neurotoxin-substance P conjugate or fusion protein for treating pain. Allergan, Dean G Stathakis, Martin A Voet, Joel B German, June 6, 2006: US07056729 (36 worldwide citation)

Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety ...



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