41
Vaghefi Farid, Chen Lan Bo, Sherman Matthew L: Bis (thio-hydrazide amides) for treament of hyperplasia. Synta Pharmaceuticals, Vaghefi Farid, Chen Lan Bo, Sherman Matthew L, DAVIS Steven G, March 30, 2006: WO/2006/033913 (17 worldwide citation)

Methods and medical devices for treating a proliferative disorder in a subject, e.g., restenosis in a blood vessel that has been implanted with a stent, employ a bis(thio-hydrazide amide) represented by Structural Formula I or a pharmaceutically acceptable salt or solvate thereof. Y is a covalent bo ...


42
Koya Keizo: Combination with bis(thiohydrazide amides) for treating cancer. Synta Pharmaceuticals, Koya Keizo, DAVIS Steven G, March 6, 2008: WO/2008/027445 (16 worldwide citation)

Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferativ ...


43
Sun Lijun, Koya Keizo, Chen Shoujun, Demko Zachary, Xia Zhi Qiang: Compounds for treating proliferative disorders. Synta Pharmaceuticals, Sun Lijun, Koya Keizo, Chen Shoujun, Demko Zachary, Xia Zhi Qiang, DAVIS Steven G, February 28, 2008: WO/2008/024302 (16 worldwide citation)

Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising c ...


44
Mcleod Matthew: Bis (thiohydrazide amides) for treating melanoma. Synta Pharmaceuticals, Mcleod Matthew, DAVIS Steven G, February 28, 2008: WO/2008/024305 (16 worldwide citation)

Disclosed herein are methods of treating lentigo maligna, superficial spreading malignant melanoma, acral lentiginous malignant melanoma or nodular malignant melanoma with bis(thio-hydrazide amides) represented by a formula selected from Structural Formulas (I)- (IX) or pharmaceutically acceptable s ...


45
Ghosh Shomir, Elder Amy M, Carson Kennth G, Sprott Kevin, Harrison Sean: Pgd2 receptor antagonists for the treatment of inflammatory diseases. Millennium Pharmaceuticals, Ghosh Shomir, Elder Amy M, Carson Kennth G, Sprott Kevin, Harrison Sean, DAVIS Steven G, April 22, 2004: WO/2004/032848 (16 worldwide citation)

Disclosed herein are compounds represented by Structural Formula (I), wherein the variables are defined herein. Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 ('CRTH2') for the tre ...


46
ECKHARDT MATTHIAS: Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline. Vitae Pharmaceuticals, Davis Steven G, May 12, 2011: WO/2011/057054 (16 worldwide citation)

The present invention relates to compounds defined by formula I, wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for trea ...


47
Huston Jared M, Tracey Kevin J: Treating inflammatory disorders by electrical vagus nerve stimulation. North Shore Long Island Jewish Research Institute, Huston Jared M, Tracey Kevin J, DAVIS Steven G, July 13, 2006: WO/2006/073484 (16 worldwide citation)

A method and an apparatus for treating a patient suffering from, or at risk for, a condition mediated by the inflammatory cytokine cascade, by electrically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.


48
Chen Shoujun, Xia Zhi Qiang, Kostik Elena, Koya Keizo, Sun Lijun: Purification of bis(thiohydrazide amides). Synta Pharmaceuticals, Chen Shoujun, Xia Zhi Qiang, Kostik Elena, Koya Keizo, Sun Lijun, DAVIS Steven G, March 20, 2008: WO/2008/033494 (15 worldwide citation)

Disclosed herein is a method for the purification of bis(thiohydrazide amide) compounds of formula I, wherein R1, R2, R3, R4, R7, R8, Z and Y are defined herein, by dissolving the compound in a solvent selected from the group consisting of tetrahydrofuran-acetone, tetrahydrofuran-acetonitrile, tetra ...


49
Jacobson Eric: Combination with bis(thiohydrazide amides) for treating cancer. Synta Pharmaceuticals, Jacobson Eric, DAVIS Steven G, February 28, 2008: WO/2008/024299 (15 worldwide citation)

Disclosed herein are methods of treating an immunosensitive cancer with bis(thio-hydrazide amides) or pharmaceutically -acceptable salts thereof and an immunotherapy.


50
Williams Martin, Mcleod Matthew, Koya Keizo: Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma. Synta Pharmaceuticals, Williams Martin, Mcleod Matthew, Koya Keizo, DAVIS Steven G, February 28, 2008: WO/2008/024301 (15 worldwide citation)

Disclosed herein are methods of preventing or delaying the recurrence of melanoma in a subject with bis(thio-hydrazide amides) represented by a formula selected from Structural Formulas (I)-(IX) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these bis(thio-hydra ...