21
CHARI Ravi V J: DÉRIVÉS DE BENZODIAZÉPINE CYTOTOXIQUES ET PROCÉDÉS DE PRÉPARATION, CYTOTOXIC BENZODIAZEPINE DERIVATIVES AND METHODS OF PREPARATION. IMMUNOGEN, CHARI Ravi V J, DAVIS Steven G, August 23, 2012: WO/2012/112708 (26 worldwide citation)

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds, such as those in formulas (V)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention ...


22
MAXWELL JOHN: Analogues for the treatment or prevention of flavivirus infections. VERTEX PHARMACEUTICALS INCORPORATED, Davis Steven G, September 29, 2011: WO/2011/119860 (26 worldwide citation)

Compounds represented by formula (I) described herein or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R1, R2, R2', R3, R3', R4, R4', R5, R5', m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.


23
KONG LAVAL CHAN CHUN: Analogues for the treatment or prevention of flavivirus infections. VERTEX PHARMACEUTICALS INCORPORATED, Davis Steven G, September 29, 2011: WO/2011/119870 (26 worldwide citation)

Compounds represented by formula (I) : or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R1, R2, R2', R3, R3', R4, R4', R5, R5'm, n, or p are as defined herein, are useful for treating flaviviridae viral infections.


24
CLAREMON DAVID A: Carbamate and urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1. VITAE PHARMACEUTICALS, Davis Steven G, December 9, 2010: WO/2010/141424 (25 worldwide citation)

This invention relates to novel compounds of the invention pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates ...


25
ALBRECHT Brian K, AUDIA James Edmund, CÔTÉ Alexandre, GEHLING Victor S, HARMANGE Jean Christophe, HEWITT Michael Charles, NAVESCHUK Christopher G, TAYLOR Alexander M, VASWANI Rishi G: INHIBITEURS DE BROMODOMAINES ET LEURS UTILISATIONS, BROMODOMAIN INHIBITORS AND USES THEREOF. CONSTELLATION PHARMACEUTICALS, ALBRECHT Brian K, AUDIA James Edmund, CÔTÉ Alexandre, GEHLING Victor S, HARMANGE Jean Christophe, HEWITT Michael Charles, NAVESCHUK Christopher G, TAYLOR Alexander M, VASWANI Rishi G, DAVIS Steven G, June 7, 2012: WO/2012/075456 (24 worldwide citation)

The present invention relates to compounds useful as inhibitors of bromodomain- containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.


26
Claremon David A, Zhuang Linghang, Tice Colin M, Ye Yuanjie, He Wei, Singh Suresh B, Xu Zhenrong, Cacatian Salvacion, Zhao Wei: Cyclic urea inhibitors of hb-hydroxysteroid dehydrogenase 1. Vitae Pharmaceutical, Claremon David A, Zhuang Linghang, Tice Colin M, Ye Yuanjie, He Wei, Singh Suresh B, Xu Zhenrong, Cacatian Salvacion, Zhao Wei, DAVIS Steven G, June 18, 2009: WO/2009/075835 (23 worldwide citation)

This invention relates to novel compounds of the Formula (I), (Ia) and (Ib), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, j which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The inve ...


27
Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Cacatian Salvacion: Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Cacatian Salvacion, DAVIS Steven G, July 30, 2009: WO/2009/094169 (23 worldwide citation)

This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie),(If), (Ig), (Ih), (Ii), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibiti ...


28
Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Xu Zhenrong, Simpson Robert D: Lactam inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Xu Zhenrong, Simpson Robert D, DAVIS Steven G, July 16, 2009: WO/2009/088997 (23 worldwide citation)

This invention relates to novel compounds of the Formula (I), (I*), (Ia), (Ib), (Ic), (Id), (Ie), (If), (If*), (Ig), (Ih), (Ij), (Ik), (ll1-3), (Im1-3), (In1-3), (lo1-2), (Ip1-9), (Iq1-9), (Ir1-9) and (Is1-3) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which a ...


29
Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M: Carbamate and urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, DAVIS Steven G, October 29, 2009: WO/2009/131669 (23 worldwide citation)

This invention relates to novel compounds of the Formula I, II, III, IHa, NIb, IV, IVa, IVb, IVc, IVd, IVe, V, Va, Vb1 Vl, Vla, VIb, VII, Vila, VIIb, VIII, Vllla, VIIIb, IX, IXa, X, and Xa, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the t ...


30
FISHKIN Nathan, MILLER Michael, LI Wei, SINGH Rajeeva: PROCÉDÉS DE PRÉPARATION DE CONJUGUÉS, METHODS OF PREPARATION OF CONJUGATES. IMMUNOGEN, FISHKIN Nathan, MILLER Michael, LI Wei, SINGH Rajeeva, DAVIS Steven G, August 23, 2012: WO/2012/112687 (22 worldwide citation)

The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.