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ELIASOF SCOTT: Polymer-agent conjugates, particles, compositions, and related methods of use. CERULEAN PHARMA, Davis Steven G, October 7, 2010: WO/2010/114770 (51 worldwide citation)

Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer- ...


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Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Boehringer Ingelheim International, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank, DAVIS Steven G, November 5, 2009: WO/2009/134400 (46 worldwide citation)

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibit ...


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Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


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Claremon David A, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Ye Yuanjie, Zhao Wei: Cyclic urea and carbamate inhibitors of 11β -hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Ye Yuanjie, Zhao Wei, DAVIS Steven G, September 4, 2008: WO/2008/106128 (38 worldwide citation)

This invention relates to novel compounds of the Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further rel ...


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Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Mcgeehan Gerard: Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Mcgeehan Gerard, DAVIS Steven G, September 24, 2009: WO/2009/117109 (38 worldwide citation)

This invention relates to novel compounds of the Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals.


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RENZ MARTIN: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Boehringer Ingelheim International, Davis Steven G, November 4, 2010: WO/2010/127237 (37 worldwide citation)

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibit ...


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Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori, DAVIS Steven G, August 5, 2004: WO/2004/064826 (37 worldwide citation)

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...


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CACATIAN SALVACION: Inhibitors of beta-secretase. Vitae Pharmaceuticals, Davis Steven G, September 16, 2010: WO/2010/105179 (35 worldwide citation)

The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.


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Claremon David A, He Wei, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Zhao Wei, Zhuang Linghang, Cacatian Salvacion, Leftheris Katerina: Cyclic inhibitors of 11β-hydroxysteriod dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, He Wei, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Zhao Wei, Zhuang Linghang, Cacatian Salvacion, Leftheris Katerina, DAVIS Steven G, February 5, 2009: WO/2009/017664 (33 worldwide citation)

This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih); (Ii); (Ij), (Ik), (II) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modu ...


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Bhagat Hitesh R, Donovan Joanne M, Braunlin William, Sacchiero Robert: Enteric coated aliphatic amine polymer bile acid sequestrants. Genzyme Corporation, Bhagat Hitesh R, Donovan Joanne M, Braunlin William, Sacchiero Robert, DAVIS Steven G, July 21, 2005: WO/2005/065291 (32 worldwide citation)

Tablets, capsules, sachets, or papers having one or more aliphatic amine polymers allow for the targeted release of the polymers at a specific region of the gastrointestinal tract, especially the small intestine. These tablets, capsules, sachets, or papers are useful in a method for lowering cholest ...