1
Benjamin Oshlack, Mark Chasin, Hua Pin Huang: Extruded orally administrable opioid formulations. Euro Celtique, Davidson Davidson & Kappel, September 28, 1999: US05958452 (253 worldwide citation)

Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed.


2
Philip J Palermo, Robert D Colucci, Robert F Kaiko: Method of preventing abuse of opioid dosage forms. Euro Celtique, Davidson Davidson & Kappel, May 8, 2001: US06228863 (242 worldwide citation)

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step ...


3
Robert F Kaiko, Robert D Colucci: Opioid agonist/opioid antagonist/acetaminophen combinations. Euro Celtique, Davidson Davidson & Kappel, April 23, 2002: US06375957 (237 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the ...


4
Benjamin Oshlack, Mark Chasin, Hua Pin Huang: Extruded multi-particulates. Euro Celtique, Davidson Davidson & Kappel, October 12, 1999: US05965161 (226 worldwide citation)

A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm a ...


5
Benjamin Oshlack, Mark Chasin, Hua Pin Huang, David Sackler: Melt-extruded orally administrable opioid formulations. Euro Celtique, Davidson Davidson & Kappel, July 17, 2001: US06261599 (189 worldwide citation)

Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques disclosed.


6
Benjamin Oshlack, Curtis Wright, J David Haddox: Tamper-resistant oral opioid agonist formulations. Euro Celtique, Davidson Davidson & Kappel, February 24, 2004: US06696088 (189 worldwide citation)

Disclosed is an oral dosage form comprising (i) an opioid agonist in releasable form and (ii) a sequestered opioid antagonist which is substantially not released when the dosage form is administered intact, such that the ratio of the amount of antagonist released from said dosage form after tamperin ...


7
Mark Chasin, Benjamin Oshlack, Frank Pedi Jr: Opioid formulations having extended controlled released. Purdue Pharma, Davidson Davidson & Kappel, September 28, 1999: US05958459 (187 worldwide citation)

Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method of 100 rp ...


8
Richard Sackler, Robert Kaiko, Paul Goldenheim: Method of treating humans with opioid formulations having extended controlled release. Purdue Pharma, Davidson Davidson & Kappel, November 7, 2000: US06143322 (184 worldwide citation)

Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method at 100 rp ...


9
Benjamin Oshlack, John K Masselink, Hua Pin Huang, Alfred P Tonelli: Controlled release hydrocodone formulations. Euro Celtique, Davidson Davidson & Kappel, May 11, 2004: US06733783 (184 worldwide citation)

A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.


10
Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Joanne Heafield, Deborah Challis: Substained release compositions and a method of preparing pharmaceutical compositions. Euro Celtique, Davidson Davidson & Kappel, October 12, 1999: US05965163 (173 worldwide citation)

A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanic ...