1
Mohan S Mahal: Flexible container material. Cutter Laboratories, David J Aston, October 30, 1984: US04479989 (183 worldwide citation)

Film material for use in sterilized medical solution containers such as blood bags or I.V. bags, comprising 30-90% linear low density polyethylene (LLDPE) and 10-70% styrene-ethylene-butylene-styrene (SEBS). The particular LLDPE and SEBS materials are selected from among known LLDPE and SEBS materia ...


2
Hesaam Esfandyarpour, Mostafa Ronaghi: Heat and pH measurement for sequencing of DNA. The Board of Trustees of the Leland Stanford Junior University, David J Aston, Peters Verny, April 26, 2011: US07932034 (117 worldwide citation)

The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a c ...


3
Stephen Quake, Hei Mun Christina Fan: Non-invasive fetal genetic screening by digital analysis. The Board of Trustees of the Leland Stanford Junior University, David J Aston, Peters Verny, February 15, 2011: US07888017 (99 worldwide citation)

The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneupl ...


4
Stephen Quake, Hei Mun Christina Fan: Determination of fetal aneuploidies by massively parallel DNA sequencing. The Board of Trustees of the Leland Stanford Junior University, David J Aston, Peters Verny, August 30, 2011: US08008018 (71 worldwide citation)

The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneupl ...


5
Hei Mun Christina Fan, Stephen R Quake: Noninvasive diagnosis of fetal aneuploidy by sequencing. The Board of Trustees of the Leland Stanford Junior University, David J Aston, Peters Verny, June 5, 2012: US08195415 (64 worldwide citation)

Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing ...


6
Robert A Tenold: Intravenously injectable immune serum globulin. Cutter Laboratories, David J Aston, Lester E Johnson, Theodore J Leitereg, February 12, 1985: US04499073 (43 worldwide citation)

A composition is disclosed which comprises a solution in a pharmaceutically acceptable carrier of an immune serum globulin, said solution having an ionic strength and a pH to maintain the monomer content and the actual and latent anticomplement activity of the immune serum globulin such that the com ...


7
Nader Pourmand, Ronald W Davis, Miloslav Karhanek: Charge perturbation detection system for DNA and other molecules. The Board of Trustees of the Leland Stanford Junior University, David J Aston, Peters Verny, August 31, 2010: US07785785 (39 worldwide citation)

Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The target molecule is preferably ...


8
W Henry Benner: Gated charged-particle trap. The Regents of the University of California, Paul R Martin, Henry P Sartorio, David J Aston, March 9, 1999: US05880466 (37 worldwide citation)

The design and operation of a new type of charged-particle trap provides simultaneous measurements of mass, charge, and velocity of large electrospray ions. The trap consists of a detector tube mounted between two sets of center-bored trapping plates. Voltages applied to the trapping plates define s ...


9
Mostafa Ronaghi, Tarun Khurana, Juan G Santiago: Method and apparatus using electric field for improved biological assays. The Board of Trustees of the Leland Stanford Junior University, David J Aston, Peters Verny, October 2, 2012: US08277628 (33 worldwide citation)

Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which ...


10
Silas W Clark: Compressor-assisted absorption refrigeration system. David J Aston, August 25, 1981: US04285211 (31 worldwide citation)

In an absorption refrigeration system comprising a generator, a condenser, an evaporator, an absorber and a heat exchanger, a compressor is provided to improve generator output and performance. The compressor is operative between the evaporator and the absorber or between the generator and condenser ...