1
Ioannis V Yannas, John F Burke, Philip L Gordon, Chor Huang: Multilayer membrane useful as synthetic skin. Massachusetts Institute of Technology, Arthur A Smith Jr, Martin M Santa, David E Brook, November 29, 1977: US04060081 (271 worldwide citation)

A multilayer membrane, which is useful as synthetic skin, is disclosed herein. A first layer is formed from a material which does not provoke an immune response and which is also insoluble and nondegradable in the presence of body fluids and/or body enzymes. Preferred materials for the first layer a ...


2
Eugene Bell: Bone-equivalent and method for preparation thereof. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, November 27, 1984: US04485097 (222 worldwide citation)

A bone-equivalent, useful in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder.


3
Ioannis V Yannas, John F Burke: Cell-seeding procedures involving fibrous lattices. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, July 10, 1984: US04458678 (212 worldwide citation)

This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which ...


4
Allen Latham Jr: Plasmapheresis apparatus. Haemonetics Corporation, David E Brook, May 2, 1978: US04086924 (200 worldwide citation)

Plasmapheresis apparatus is disclosed which comprises a unique combination of blood withdrawal, separation and return means, together with automatic cycle control means. This apparatus can withdraw whole blood from a donor, separate it into plasma and non-plasma components, and return the non-plasma ...


5
Ioannis V Yannas, Philip L Gordon, Chor Huang, Frederick H Silver, John F Burke: Crosslinked collagen-mucopolysaccharide composite materials. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, July 28, 1981: US04280954 (197 worldwide citation)

Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures ...


6
Eugene Bell: Tissue-equivalent and method for preparation thereof. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, November 27, 1984: US04485096 (189 worldwide citation)

A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a contractile agent, such as fibroblast cells or blood platelets, to form tissue-equivalent. In one embodimen ...


7
John C C Fan, Herbert J Zieger: Method of crystallizing amorphous material with a moving energy beam. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, January 5, 1982: US04309225 (178 worldwide citation)

An improved method for crystallizing amorphous material with a moving beam of energy is disclosed. In this method, the energy beam is scanned in a manner to provide controlled, continuous motion of the crystallization front.


8
John C C Fan, Herbert J Zeiger: Method for improving the crystallinity of semiconductor films by laser beam scanning and the products thereof. Massachusetts Institute of Technology, Arthur A Smith Jr, Martin Santa, David E Brook, November 22, 1977: US04059461 (147 worldwide citation)

A method is disclosed for improving the crystallinity of semiconductor films by scanning the surface of such films with a shaped, focused laser beam. The laser is matched to the film so that the beam delivers sufficient energy thereto to heat the film above a temperature at which crystallization occ ...


9
Ioannis V Yannas, John F Burke, Dennis P Orgill, Eugene M Skrabut: Method of promoting the regeneration of tissue at a wound. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, December 6, 1983: US04418691 (135 worldwide citation)

This invention comprises the use of centrifugal force to introduce viable cells into a fibrous lattice, as well as fibrous lattices that are seeded with cells by the use of centrifugal force. A variety of fibrous lattices may be seeded by the methods of this invention, such as a highly porous lattic ...


10
Ioannis V Yannas, John F Burke: Method of using a fibrous lattice. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, March 19, 1985: US04505266 (113 worldwide citation)

This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which ...