1
Frederic L Clark, Gilbert Clift, Kendall B Hendrick, William J Kanewske III, Peter A Lagocki, Richard R Martin, James E Mitchell, Larry W Moore, Charles D Pennington, Edna S Walker, B Jane Smith, Apparao Tayi, James A Vaught, David A Yost: Automated continuous and random access analytical system. Abbott Laboratories, Daniel W Collins, James L Wilcox, October 25, 1994: US05358691 (182 worldwide citation)

An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on th ...


2
Alfred C Greenquist: Multizone analytical element having labeled reagent concentration zone. Miles, Daniel W Collins, February 21, 1989: US04806311 (165 worldwide citation)

A multizone test device for the determination of analyte from a liquid test medium upon contact with the liquid test medium and a labeled reagent comprising a chemical group having a detectable physical property. The test device preferably comprises multilayers including a reagent layer incorporated ...


3
Alfred C Greenquist: Multizone analytical element having detectable signal concentrating zone. Miles, Daniel W Collins, February 21, 1989: US04806312 (121 worldwide citation)

A multizone test device for the determination of analyte from a liquid test medium upon contact with the liquid test medium and a labeled reagent comprising a chemical group having a detectable chemical property. The test device preferably comprises multilayers including a reagent layer incorporated ...


4
Paul F Corey: Chromogenic acridinone enzyme substrates. Miles, Daniel W Collins, March 7, 1989: US04810636 (120 worldwide citation)

Chromogenic acridinone enzyme substrate compounds comprising 7-hydroxy-9H-acridin-2-one chromogens derivatized at the 7-hydroxy-position with an enzymatically-cleavable group and disubstituted at the 9-position with alkyl or aryl groups, which can be the same or different, preferably lower alkyl or ...


5
Omar S Khalil, Thomas F Zurek, Kevin R Genger, Curtis J Pepe, Yi Her Jou, Stephen M Cotter: Method and apparatus for heterogeneous chemiluminescence assay. Abbott Laboratories, Priscilla E Porembski, Daniel W Collins, February 18, 1992: US05089424 (105 worldwide citation)

Apparatus and method for performing a chemiluminescence assay involving the immobilization of a chemiluminescent reaction complex to a solid, porous element. The solid, porous element is preferably treated to provide an immobilizing interaction with the chemiluminescent reaction complex wherein the ...


6
Diane L Aunet, Gradimir G Gerogevich, Tzyy Wen Jeng, Gary M Oosta, Neal A Siegel: Methods and devices for the separation of plasma or serum from whole blood. Abbott Laboratories, Priscilla E Porembski, Daniel W Collins, Thomas D Brainard, June 12, 1990: US04933092 (85 worldwide citation)

A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole b ...


7
Robert C Hollar, Tung Ming Huang: Unitized reagent containment system for clinical analyzer. Abbott Laboratories, Daniel W Collins, Clifford A Dean, Robert W Stevenson, June 12, 1990: US04933147 (80 worldwide citation)

Improvements in apparatus for performing an assay to determine the presence or amount of a substance in a test sample, which apparatus comprises means for dispensing one or more reagents from containment means therefor into a reaction vessel and means for dispensing the sample from a sample containe ...


8
John G Pumphrey, Benton A Durley III, Paul E Garrett, Edward G Pumphrey, Charles L Davis, Frederic L Clark, Lawrence Spritzer: Apparatus for measuring electrolytes utilizing optical signals related to the concentration of the electrolytes. Abbott Laboratories, John W Cornell, Daniel W Collins, Richard D Schmidt, March 19, 1991: US05001417 (73 worldwide citation)

Apparatus for measuring electrolyte concentrations in fluid samples. The apparatus includes an ion selective electrode having a plurality of ion selective detection sites. Each site has an affinity for a preselected electrolyte of interest and generates a potential having a magnitude related to the ...


9
Omar S Khalil, Charles F Hanna, Denise G Huff, Thomas F Zurek: Device for performing solid-phase diagnostic assay. Abbott Laboratories, Frank S Ungemach, Priscilla E Porembski, Daniel W Collins, September 14, 1993: US05244630 (66 worldwide citation)

A disposable device suitable for performing automated solid-phase diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detached by o ...


10
David L Woodrum: Reversible immobilization of assay reagents in a multizone test device. Miles, Andrew L Klawitter, Daniel W Collins, September 25, 1990: US04959305 (65 worldwide citation)

A multizone test device for the determination of analyte in a liquid test medium. The test device preferably comprises multilayers including a first layer comprising a solid, porous matrix incorporated with a reversibly immobilized first reagent and a second layer comprising a solid, porous matrix i ...