1
Peter E Daddona, Gregory T Fieldson, Avtar S Nat, Wei Qi Lin: Minimally invasive detecting device. Alza Corporation, D Byron Miller, Steve F Stone, July 18, 2000: US06091975 (776 worldwide citation)

An agent detecting device comprising a plate (6) having a plurality of microprotrusions (4) for piercing the skin of a patient. Each of the microprotrusions (4) having an electrode (14, 16 and 18) thereon for detecting the presence of an agent in the patient's interstitial fluid.


2
Michel J N Cormier, Felix T Theeuwes: Device and method for enchancing transdermal sampling. Alza Corporation, Owen J Bates, D Byron Miller, Steven F Stone, April 17, 2001: US06219574 (647 worldwide citation)

A percutaneous agent sampling device and method are provided. The device comprises a collector and a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent.


3
Michel J N Cormier, Avtar S Nat, Armand P Neukermans, Barry Block: Device for enhancing transdermal agent delivery or sampling. Alza Corporation, Owen J Bates, D Byron Miller, Steven F Stone, May 8, 2001: US06230051 (268 worldwide citation)

A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent. The microblades having a relatively sharp angled leading edge which transitions to a relatively gradually angled blade edge.


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Gary A Lattin, Thomas A Riddle: Electrotransport system with remote telemetry link. Alza Corporation, D Byron Miller, Felissa H Cagan, Steve F Stone, September 3, 1996: US05551953 (240 worldwide citation)

An electrotransport system (20) for delivering a therapeutic agent (36) through a body surface (40) (eg, skin) of a patient includes a pair of electrodes (34, 38) for contacting the body surface, at least one of which contains the therapeutic agent (36). The system (20) is physically separated into ...


6
Joseph Creagan Trautman, Michel J N Cormier, Hyunok Lynn Kim, Michael G Zuck: Device for enhancing transdermal agent flux. ALZA Corporation, D Byron Miller, Steven F Stone, July 4, 2000: US06083196 (227 worldwide citation)

A device (3) comprising a sheet member (6) having a plurality of microprotrusions (4) for penetrating the skin and a substantially incompressible agent reservoir housing (15) contacting and extending across the sheet member (6) for transmitting a hold-down force applied the sheet member (6) to maint ...


7
Ronald P Haak, Felix Theeuwes, J Richard Gyory: Electrotransport transdermal system. Alza Corporation, D Byron Miller, Steven F Stone, Edward L Mandell, May 22, 1990: US04927408 (155 worldwide citation)

A transdermal therapeutic system which utilizes electrical current to facilitate agent delivery and which isolates the electrochemical reactants and products from the agent containing reservoir.


8
Eun S Lee, Victor Goetz: Abusable substance dosage form having reduced abuse potential. Alza Corporation, Steven F Stone, D Byron Miller, Paul L Sabatine, August 17, 1993: US05236714 (138 worldwide citation)

Compositions and dosage forms for administering abusable substances are disclosed which have a reduced potential for abuse without diminishing the therapeutic or beneficial effects of the abusable substance. Topical compositions for application to the skin or mucosa contain the abusable substance in ...


9
Michael G Zuck: Device for enhancing transdermal agent flux. ALZA Corporation, D Byron Miller, Steven F Stone, April 18, 2000: US06050988 (136 worldwide citation)

A device (2) comprising a sheet member (6) having a plurality of microprotrusions (4) extending from a bottom edge (5) for penetrating the skin of a patient. The sheet member (6) when in use being oriented in an approximately perpendicular relation to the patient's skin.


10
J Richard Gyory, John R Perry: Iontophoretic delivery device and method of hydrating same. Alza Corporation, D Byron Miller, R Scott Meece, Steven F Stone, May 10, 1994: US05310404 (112 worldwide citation)

A dry-state iontophoretic drug delivery device (10, 30) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. In one embodiment of the invention, a sealed liquid-containing pouch (21, 22) is provided in each electrode assembly (8, 9). W ...