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John Robert Adair, Diljeet Singh Athwal, John Spencer Emtage: Humanized antibodies. Celltech Therapeutics, Cozen O&apos Connor P C, October 14, 2003: US06632927 (274 worldwide citation)

CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions (6, 23) and/or (24, 48) and/or (49, 71) and/or (73, 75) and/or (76) and/or (78) and (88) and/or (91). The CDR-grafted lig ...


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Chen W Liaw, Dominic P Behan, Derek T Chalmers: Non-endogenous, constitutively activated human protein-coupled receptors. Arena Pharmaceuticals, Cozen O&apos Connor P C, April 29, 2003: US06555339 (33 worldwide citation)

Disclosed are constitutively activated, non-endogenous versions of endogenous human GPCRs comprising the following amino acid sequence region (C-terminus to N-terminus orientation) and/or the following nucleic acid sequence region (3′ to 5′ orientation) transversing the transmembrane-6 (TM6) and int ...


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Michael Antoniou, Robert Crombie: Polynucleotide. M L Laboratories, Cozen O&apos Connor P C, February 10, 2004: US06689606 (12 worldwide citation)

The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or ...


5
David B Weiner, Joo Sung Yang: Highly expressible genes. The Trustees of the University of Pennsylvania, Cozen O&apos Connor P C, May 11, 2004: US06733994 (12 worldwide citation)

The present invention provides methods of producing protein in a recombinant expression system that comprises translation of mRNA transcribed from a heterologous DNA sequence in the expression system, said method comprising the steps of predicting the secondary structure of mRNA transcribed from a n ...


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Mark I Greene, James Eberwine, Janet Estee Kacharmina, Hong Tao Zhang: Methods, systems and kits for immuno-detection of epitopes expressed on molecules. The Trustees of the University of Pennsylvania, Cozen O&apos Connor P C, June 1, 2004: US06743592 (11 worldwide citation)

Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide.


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David Ruffin Burnette: Electrical metallic tube, coupling, and connector apparatus and method. Jonn Maneely Company, Cozen O&apos Connor P C, Michael B Fein, Brian L Belles, September 28, 2004: US06797877 (9 worldwide citation)

A labor saving system, method, and apparatus for connecting or coupling lengths of electric metallic tubing (“EMT”). The invention uses couplings/connectors that have barbs that are designed to engage corresponding indentations on EMT to ensure proper installation. In one aspect, the invention is an ...


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Roger K Craig: Methods for vaccination and vaccines therefor. M L Laboratories, Cozen O&apos Connor P C, February 10, 2004: US06689757 (8 worldwide citation)

The invention relates to methods of and compositions for vaccinating a mammal against a disease, wherein a mixture is administered which includes (i) a nucleic acid which encodes a first epitope and (ii) a peptide containing a second epitope such that both of the nucleic acid and the second epitope ...


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Linda Kay Jolliffe, Robert Allan Zivin, John Robert Adair, Diljeet Singh Athwal: CD3 specific recombinant antibody. Celltech R&D, Cozen O&apos Connor P C, June 15, 2004: US06750325 (7 worldwide citation)

The invention provides recombinant antibody molecules comprising antigen binding regions derived from the heavy and/or light chain variable regions of a donor anti-CD3 antibody, e.g. OKT3, and which have anti-CD3 binding specificity, preferably of affinity similar to that of OKT3. The recombinant an ...


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Herbert Chao, Nan Tian, Alain Drexler, John Schmidhauser: Hydroxyl-terminated polybutadienes and curing formulations. Sartomer Technologies Company, Michael B Fein, Cozen O&apos Connor P C, June 8, 2004: US06747097 (6 worldwide citation)

Compositions comprising (A) non-branched polybutadiene having terminal hydroxyl functionality less than 2 per molecule by average; and (B) branched polybutadiene having terminal hydroxyl functionality more than 2 per molecule by average; the weight ratio of (A) to (B) being about 99:1 to 1:99. These ...