51
Jack W Szostak, Richard W Roberts, Rihe Liu: Nucleic acid-protein fusion molecules and libraries. The General Hospital Corporation, Clark & Elbing, August 28, 2001: US06281344 (46 worldwide citation)

Described herein are methods and reagents for the selection of protein molecules that make use of RNA-protein fusions.


52
Sherin S Abdel Meguid, Robert E Babine, Hongfeng Deng, Lei Jin, Jian Lin, Scott R Magee, Harold V Meyers, Pramod Pandey, Michael J Rynkiewicz, David T Weaver, Zihong Gho, Thomas D Bannister: Compounds and methods for treatment of thrombosis. Daiamed, Clark & Elbing, Paul T Clark, May 15, 2007: US07217794 (46 worldwide citation)

The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting addition ...


53
Jack W Szostak, Richard W Roberts: RNA-antibody fusions and their selection. The General Hospital Corporation, Clark & Elbing, February 11, 2003: US06518018 (46 worldwide citation)

Described herein are methods and reagents for the selection of protein molecules that make use of RNA-protein fusions.


54
Charles L Dennis, George J Klein, Ursula Gebhardt, Kenneth M Anderson, Glenn C Zillmer: Intravascular medical device. Clark & Elbing, Kristina Bieker Brady, December 13, 2011: US08078279 (44 worldwide citation)

An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vascula ...


55

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Brian Seed, Jan Holgersson: Fucosyltransferase genes and uses thereof. The General Hospital Corporation, Clark & Elbing, January 12, 1999: US05858752 (44 worldwide citation)

Purified DNA encoding .alpha.(1,3)fucosyltransferase and the recombinant proteins expressed from such DNA are disclosed. The recombinant fucosyltransferase polypeptides are used to fucosylate proteins to produce therapeutics useful for the treatment of disease, e.g., an adverse immune reaction such ...


57
Clyde Lewis Schultz, Janet M Mint: Drug delivery system for antiglaucomatous medication. Clark & Elbing, June 25, 2002: US06410045 (43 worldwide citation)

A drug delivery system for antiglaucomatous medications utilizing a polymeric hydrogel which can absorb an ophthalmic medication which can then be transferred into the ocular fluid of the eye.


58
Hans Arne Hansson, Michael R Wells, Samuel E Lynch, Harry N Antoniades: Device to promote drug-induced nerve regeneration. Institute of Molecular Biology, Clark & Elbing, August 12, 1997: US05656605 (42 worldwide citation)

The invention relates generally to a system for promoting regeneration of a damaged nerve. In particular, the invention comprises: (1) a guide tube constructed to be attached to the damaged nerve; (2) guiding filaments disposed within the guide tube; and, (3) a therapeutic composition enclosed by th ...


59
F Donald Roberts, Phillip M Friden, Peter Spacciapoli, Eric Nelson: Use of locally delivered metal ions for treatment of periodontal disease. Periodontix, Clark & Elbing, November 28, 2000: US06153210 (41 worldwide citation)

Periodontal disease can be treated by the administration of metal ions, preferably silver ions, to the site where the microorganisms that cause this disease reside. Administration can be to periodontal pockets or adjacent to exposed tooth roots or alveolar bone during periodontal surgical procedures ...


60
Ronald Colin Garner, David J Phillips, Timothy G Wilkinson, Frank G Angella, Erwin R Dorland, Martin W Stow: Marking of products to establish identity and source. Biocode, Clark & Elbing, July 7, 1998: US05776713 (40 worldwide citation)

In general, the invention features a method of marking a product for identification in which a marker, composed of a low molecular weight hapten covalently bound to a compound, is associated with the product. Where the marker is non-deleterious to the product, inert with respect to the product, and ...