1
Dosuk D Lee, Atul Nagras, Pramod Chakravarthy, Anthony M Majahad: Surface modification of medical implants. Etex Corporation, Mary Rose Scozzafava, Clark & Elbing, March 7, 2000: US06033582 (333 worldwide citation)

An irregularly etched medical implant device is provided having random non-uniform relief patterns on the surface ranging from about 0.3 .mu.m to less than about 20 .mu.m in depth. The random, irregular surface as defined by the etch micromorphology and respective dimensional properties are obtained ...


2
Dosuk D Lee, Christian Rey, Maria Aiolova: Bioresorbable ceramic composites. Etex Corporation, Clark & Elbing, February 22, 2000: US06027742 (234 worldwide citation)

A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intramuscular or subcutaneous site, resorption of a ...


3
Dosuk D Lee, Christian Rey, Maria Aiolova: Preparation of cell seeded ceramic compositions. Etex Corporation, Mary Rose Scozzafava, Clark & Elbing, October 31, 2000: US06139578 (180 worldwide citation)

The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vi ...


4
Dosuk D Lee, Christian Rey, Maria Aiolova: Cartilage growth from cell seeded ceramic compositions. Etex Corporation, Clark & Elbing, August 21, 2001: US06277151 (165 worldwide citation)

The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vi ...


5
Venkatram R Shastri, Christine E Schmidt, Robert S Langer, Joseph P Vacanti: Neuronal stimulation using electrically conducting polymers. Children s Medical Center Corporation, Massachusetts Institute of Technology, Mary Rose Clark & Elbing Scozzafava, August 1, 2000: US06095148 (141 worldwide citation)

Methods and support systems are provided for modifying the regeneration, differentiation, or function of cells. In one embodiment, electrically conducting biocompatible polymers may be used alone or in combination with a polymeric support for in vitro nerve cell regeneration, or in vivo to aid in he ...


6
Dosuk D Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi: Method of preparing a poorly crystalline calcium phosphate and methods of its use. Etex Corporation, Paul T Clark, Clark & Elbing, October 11, 2005: US06953594 (140 worldwide citation)

The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrat ...


7
Dosuk D Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi: Methods and products related to the physical conversion of reactive amorphous calcium phosphate. Etex Corporation, Mary Rose Scozzafava, Clark & Elbing, September 12, 2000: US06117456 (135 worldwide citation)

The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrat ...


8
Venkatram R Shastri, Ivan Martin, Robert S Langer, Joachim Seidel: Three-dimensional polymer matrices. Massachusetts Institute of Technology, Kristina Bieker Brady, Clark & Elbing, October 29, 2002: US06471993 (135 worldwide citation)

Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed. Methods for preparing these matrices are also disclosed.


9
Dosuk D Lee, Christian Rey, Maria Aiolova: Bone substitution material and a method of its manufacture. Etex Corporation, Mary Rose Scozzafava, Clark & Elbing, April 10, 2001: US06214368 (126 worldwide citation)

The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provi ...


10
Donald A G Mickle, Ren Ke Li, Richard D Weisel: Transplants for myocardial scars. Genzyme Corporation, Clark & Elbing, August 8, 2000: US06099832 (107 worldwide citation)

A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.