1
Erik T Engelson: Catheter for guide-wire tracking. Target Therapeutics, Ciotti & Murashige Irell & Manella, April 26, 1988: US04739768 (389 worldwide citation)

A catheter for use with a guide wire which can be guided from an external body access site to an internal tissue, and into the tissue along a tortuous path of at least about 5 cm through vessels of less than about 3 mm lumen inner diameter. The catheter includes a relatively stiff proximal segment d ...


2
Donald G Wallace, Hertsel Reihanian, Bruce B Pharriss, William G Braun: Injectable implant composition having improved intrudability. Collagen Corporation, Ciotti & Murashige Irell & Manella, February 7, 1989: US04803075 (298 worldwide citation)

Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.


3
Philippe M Frossard: Apo AI/CIII genomic polymorphisms predictive of atherosclerosis. Biotechnology Research Partners, Ciotti & Murashige Irell & Manella, January 31, 1989: US04801531 (280 worldwide citation)

The invention offers an early detection method for atherosclerosis using genetic analysis to detect a polymorphisms shown to be correlated with this disease which are proximal to the apolipoprotein AI (apoAI) and aplipoprotein CIII (apoCIII) gene complex. All individuals with a 300 bp deletion 4 kb ...


4
Francis J Martin, Jacqueline K Morano: Liposome extrusion method. Liposome Technology, Ciotti & Murashige Irell & Manella, April 12, 1988: US04737323 (233 worldwide citation)

A suspension of liposomes whose sizes are predominantly greater than about 1 micron is passed through an asymmetric ceramic filter whose inner-surface pore size is about 1 micron. The processed liposomes have a selected average size of about 0.4 microns or less, depending on the number of filter cyc ...


5
Mickey S Urdea: Polynucleotide determination with selectable cleavage sites. Chiron Corporation, Ciotti & Murashige Irell & Manella, October 4, 1988: US04775619 (190 worldwide citation)

Methods for diagnosis employing polynucleotides having oligonucleotide sequences substantially homologous to a sequence of interest, where the presence or absence of hybridization at a predetermined stringency provides for the release of a label from a support. Particularly, various techniques are e ...


6
Karl A Piez, Bruce B Pharriss, George H Chu, Thomas L Smestad, Diana Hendricks: Xenogeneic collagen/mineral preparations in bone repair. Collagen Corporation, Ciotti & Murashige Irell & Manella, January 3, 1989: US04795467 (188 worldwide citation)

A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new ...


7
Donald G Wallace, Thomas L Smestad, John M McPherson, Karl A Piez, Saeid Seyedin, Rosa Armstrong: Methods of bone repair using collagen. Collagen Corporation, Ciotti & Murashige Irell & Manella, December 6, 1988: US04789663 (186 worldwide citation)

A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be ly ...


8
John Urquhart, Harold R Elgie: Contingent dosing device. Aprex Corporation, Ciotti & Murashige Irell & Manella, February 16, 1988: US04725997 (180 worldwide citation)

A contingent dosing device which actively controls the pattern in which doses of one or more pharmaceutical preparations are administered to a patient. The device is programmed with information concerning an initial dosing regimen, and monitors deviations from that regimen. Based on the acceptabilit ...


9
Lawrence S Cousens, Patricia A Tekamp Olson, Jeffrey R Shuster, James P Merryweather: Expression using fused genes providing for protein product. Chiron Corporation, Ciotti & Murashige Irell & Manella, June 14, 1988: US04751180 (175 worldwide citation)

Novel methods and compositions are provided for enhanced yield of heterologous proteins in fungi. The method and compositions involve employing fusion sequences involving a sequence encoding a heterologous product produced in relatively large amount as a stable polypeptide in the host fused to a sec ...


10
George Chu: Collagen/mineral mixing device and method. Collagen Corporation, Ciotti & Murashige Irell & Manella, May 10, 1988: US04743229 (167 worldwide citation)

A mixing device for preparing inductive and conductive bone repair compositions is disclosed, along with a method for using the device for preparing such compositions. The device provides a simple and rapid method of making a substantially uniform collagen/mineral bone implant preparation.