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Alejandro A Aruffo, Diane Hollenbaugh, Anthony W Siadak, Karen K Berry, Linda Harris, Barbara A Thorne, Jurgen Bajorath: Antibodies against human CD40. Bristol Myers Squibb Co, Christopher A Klein, Audrey F Sher, April 18, 2000: US06051228 (81 worldwide citation)

The Applicants have discovered a novel antibody, more specifically a chimerized anti-human CD40 monoclonal antibody, which blocks the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent ant ...


2
Glen E Mikesell, Han Chang, Robert J Peach: Antibodies directed to B7-related polypeptide, BSL-2. Bristol Myers Squibb Company, Stephen C D Amico, Caryn Dehoratius, Christopher A Klein, November 15, 2005: US06965018 (45 worldwide citation)

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, ...


3
Glen Eugene Mikesell, Han Chang, Robert James Peach: Polynucleotides-encoding B7-related polypeptide, BSL2-L165-35B. Bristol Myers Squibb Company, Stephen C D Amico, Christopher A Klein, October 9, 2007: US07279567 (39 worldwide citation)

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, ...


4
Anthony W Siadak, Diane L Hollenbaugh, Lisa K Gilliland, Marcia L Gordon, Jurgen Bajorath, Alejandro A Aruffo: Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy. Bristol Myers Squibb Company, Christopher A Klein, Brian W Poor, Joseph M Sorrentino, March 2, 1999: US05876950 (34 worldwide citation)

The present invention provides monoclonal antibodies, antigen binding fragment and recombinant binding proteins specific for human gp39. These antibodies are specific for at least eight different epitopes on gp39. Hybridomas secreting specific antibodies which bind to these epitopes are also provide ...


5
Kanakaraju Koduri, John T Miller, Pallaiah Thammana: Expression vectors containing hot spot for increased recombinant protein expression in transfected cells. Briana C Buchholz, Audrey F Sher, Christopher A Klein, February 18, 2003: US06521419 (28 worldwide citation)

A specific locus (hot spot) for recombinant gene expression has been identified in the genome of Chinese hamster ovary cells. A DNA vector containing the hot spot causes high levels of recombinant gene expression following transfection and stable integration. The selection and cloning of the specifi ...


6
Dalton King, Raymond A Firestone, Pamela Trail: Branched hydrazone linkers. Bristol Myers Squibb Company, Keith R Lange, Audrey F Sher, Christopher A Klein, January 28, 2003: US06512101 (24 worldwide citation)

Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.


7
Suo W Liu, Thomas J Franceschini: High expression Escherichia coli expression vector. Bristol Myers Squibb Company, Christopher A Klein, Thomas R Savitsky, May 30, 2000: US06068991 (18 worldwide citation)

High expression vectors for expression of heterologous genes in Escherichia coli. The expression vectors contain, the tac promoter, an intergenic region, a restriction site, and, optionally, groES DNA.


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Kanaka Raju Koduri, John T Miller, Pallaiah Thammana: Expression vectors containing hot spot for increased recombinant protein expression in transfected cells. Bristol Myers Squibb Company, Briana C Buchholz, Christopher A Klein, October 5, 2004: US06800457 (13 worldwide citation)

A specific locus (hot spot) for recombinant gene expression has been identified in the genome of Chinese hamster ovary cells. A DNA vector containing the hot spot causes high levels of recombinant gene expression following transfection and stable integration. The selection and cloning of the specifi ...


10
John M Voita: Fabrication and installation of steel reinforcement cages for pier foundations. Christopher A Klein, James Duffy, November 1, 1994: US05359829 (9 worldwide citation)

A method and apparatus for fabricating a drilled, concrete pier in the earth at a construction site is disclosed. The method comprises the steps of providing a template from which vertical reinforcement bars may be suspended and disposed in spatial alignment generally defining the periphery of the r ...