1
Vick Bertrand, Caspari Matthew, Radaelli Guido: Methods and compositions for production and purification of biofuel from plants and microalgae. Aurora Biofuels, Vick Bertrand, Caspari Matthew, Radaelli Guido, CHEN Shirley, May 22, 2008: WO/2008/060571 (73 worldwide citation)

Methods and compositions are provided for producing purified oil from an organism, whether these organisms are wild type, selectively bred or genetically modified, and are suitable for the large scale production of an oil product. The organism may be an animal, a plant or a microorganism such as yea ...


2
Redkar Sanjeev, Phiasivongsa Pasit: Salts of 5-azacytidine. Supergen, Redkar Sanjeev, Phiasivongsa Pasit, CHEN Shirley, March 30, 2006: WO/2006/034154 (14 worldwide citation)

The present invention relates to salts of 5-azacytidine as well as methods for synthesizing the salts described herein. Pharmaceutical compositions and methods of using the 5-azacytidine salts are also provided, including methods of administering the salts or pharmaceutical compositions thereof to t ...


3
Lyons John, Chang Lucy: Composition and method for treating neurological disorders. Supergen, Lyons John, Chang Lucy, CHEN Shirley, February 3, 2005: WO/2005/009349 (12 worldwide citation)

Compositions, kits and methods are provided for treating or preventing neurological disorders associated with aberrant silencing of gene expression by reestablishing the gene expression through inhibition of DNA methylation and/or histone deacetylase. The compositions and methods include administeri ...


4
Bacus Sarah S, Smith Bradley L: Method for predicting the response to her2-directed therapy. Ventana Medical Systems, Cell Signaling Technology, CHEN Shirley, June 24, 2004: WO/2004/053497 (9 worldwide citation)

This invention provides methods for determining or predicting response to HER2-directed therapy in an individual.


5
Tang Chunlin, Joshi Hangal Rajashree: Pharmaceutical formulations cytidine analogs and derivatives. Supergen, Tang Chunlin, Joshi Hangal Rajashree, CHEN Shirley, June 15, 2006: WO/2006/063111 (6 worldwide citation)

The present invention provides pharmaceutical formulations of cytidine analogs and derivatives, such as 5­-azacytidine, 5-aza-2’-deoxy-2’,2’-difluorocytidine, 5-aza-2’-deoxy-2’-fluorocytidine, 2’-deoxy-2’,2’­difluorocytidine, and cytosine 1-ß-D-arabinofuranoside, as well as methods of manufacturing ...


6
Zhong Pingyu, Luo Peizhi, Wang Kevin C, Hsieh Mark, Li Yan: Humanized antibodies against vascular endothelial growth factor. Abmaxis, Zhong Pingyu, Luo Peizhi, Wang Kevin C, Hsieh Mark, Li Yan, CHEN Shirley, June 16, 2005: WO/2005/054273 (6 worldwide citation)

Methods are provided for designing and selecting antibodies against human antigens with high affinity and specificity in silico and in vitro. In some particular embodiments, methods are provided for designing and selecting humanized or fully human antibodies against vascular endothelial growth facto ...


7
Lovell Stephen, Blank Lydia, Crews Virginia, Hasse Nancy, Lu Peter, Schweizer Johannes: Method of protein extraction from cells. Becton Dickinson And Company, Arbor Vita Corporation, Lovell Stephen, Blank Lydia, Crews Virginia, Hasse Nancy, Lu Peter, Schweizer Johannes, CHEN Shirley, November 22, 2007: WO/2007/134252 (6 worldwide citation)

Methods for producing a protein extract from cells, such as cells containing viral proteins, are provided. In general terms, the methods involve: increasing the pH of the cells to a pH of at least about pH 10.0 to produce an intermediate composition, and then, in the presence of a non-ionic detergen ...


8
Phiasivongsa Pasit, Redkar Sanjeev: Azacytosine analogs and derivatives. Supergen, Phiasivongsa Pasit, Redkar Sanjeev, CHEN Shirley, September 21, 2006: WO/2006/099132 (5 worldwide citation)

Compounds and compositions of azacytosine analogs and derivatives are provided. In one aspect of the invention, analogs or derivatives of decitabine and azacitidine are provided with modification at the 2-, 4-, or 6- position of the triazine ring, at the 1'-6' position of the ribose ring, or combina ...


9
Tang Chunlin, Joshi Hangal Rajashree: Pharmaceutical formulation of decitabine. Supergen, Tang Chunlin, Joshi Hangal Rajashree, CHEN Shirley, July 6, 2006: WO/2006/071491 (4 worldwide citation)

The present invention provides pharmaceutical formulations of decitabine or 5-aza-2’-deoxycytidine as well as methods of manufacturing the formulations. In particular, decitabine is formulated with a cyclodextrin compound to stabilize and/or enhance solubility of the drug. Kits and methods for using ...


10
Wrenn Simeon M, Rubinfeld Joseph: Camptothecin conjugates. Supergen, Wrenn Simeon M, Rubinfeld Joseph, CHEN Shirley, October 11, 2001: WO/2001/074402 (1 worldwide citation)

Disclosed is a compound that includes a camptothecin conjugated to a lactone ring protecting moiety. Also disclosed are compositions and kits including the compound, and methods of making and usign the compound.



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