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Arnold I Caplan, Stephen E Haynesworth: Human mesenchymal stem cells. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, January 23, 1996: US05486359 (513 worldwide citation)

Isolated human mesenchymal stem cells which can differentiate into more than one tissue type (e.g. bone, cartilage, muscle or marrow stroma), a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. "mesenchymal stem cells" or "hMSCs"), and characterization of a ...


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Arnold I Caplan, Stephen E Haynesworth: Connective tissue regeneration using human mesenchymal stem cell preparations. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, September 22, 1998: US05811094 (262 worldwide citation)

Isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression profiling) and uses, particularly research reagent, diagnostic and therap ...


3
Giovanni Berti, William I White, Rodric H White Stevens: Test means and method for interference resistant determination of oxidizing substances. Miles Laboratories, Charles J Herron, January 27, 1981: US04247297 (258 worldwide citation)

Test means, such as a composition or device, method of making a test device and process for determination of at least one oxidizing substance, such as a peroxide, are disclosed. More particularly, the contemplated test means comprises a hydrazone and 8-amino-1-napthol-5,7-disulfonic acid (Chicago ac ...


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Stanton L Gerson, Arnold I Caplan, Stephen E Haynesworth: Transduced mesenchymal stem cells. Case Western Reserve University, Charles J Herron, Elliot M Olstein, January 7, 1997: US05591625 (174 worldwide citation)

Genetically engineered human stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins or for use in gene therapy. In addition to correction of genetic disorders, is the ability to introduce, in a targeted manner, addi ...


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Scott P Bruder, Arnold I Caplan, Stephen E Haynesworth: Lineage-directed induction of human mesenchymal stem cell differentiation. Case Western Reserve University, Charles J Herron, Elliot M Olstein, April 7, 1998: US05736396 (164 worldwide citation)

Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including i ...


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Elazar Rabbani, Dean L Engelhardt: Composition and method for the detection of the presence of a polynucleotide sequence of interest. Enzo Biochem, Charles J Herron, July 5, 1988: US04755458 (146 worldwide citation)

The present invention relates to a wide range of genetic analyses using the technique of nucleic acid hybridization. These genetic analyses include, for example, the diagnosis of infections by foreign microbes and the detection of specific genetic traits and abnormalities. More specifically, the pre ...


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Dean L Englehardt, Elazar Rabbani: Hybridization method for the detection of genetic material. Enzo Biochem, Charles J Herron, Serle I Mosoff, January 16, 1990: US04894325 (135 worldwide citation)

This invention provides methods for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods for the detection of mutations. Also provided are components for use in such methods.


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Mark F Pittenger: Adipogenic differentiation of human mesenchymal stem cells. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, October 27, 1998: US05827740 (121 worldwide citation)

A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogenic lineage, and a process for indu ...


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Jonathan Stamler, Joseph Loscalzo, Adam Slivka, Daniel Simon, Robert Brown, Jeffrey Drazen: S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof. Brigham and Women s Hospital, Charles J Herron, Elliot M Olstein, January 10, 1995: US05380758 (93 worldwide citation)

S-nitrosothiols exert a potent relaxant effect, mediated both by guanylate cyclase, and a cGMP-independent mechanism, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Thus, S-nitrosothiols may be used for the treat ...


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