1
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, September 24, 1996: US05559213 (84 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


2
John Hakimi, Patricia Kilian, Perry Rosen: Polymer for making poly(ethylene glycol)-protein conjugates. Hoffmann La Roche, George M Gould, William H Epstein, Catherine R Smith, July 23, 1996: US05539063 (50 worldwide citation)

The present invention is a polymer which may be used to produce a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic ...


3
Thomas McGee, Saroja Narasimhan, Caryl E Yeager: Low VOC perfume formulations. Givaudan Roure Corporation, George W Johnston, Catherine R Smith, Mark E Waddell, December 17, 1996: US05585343 (30 worldwide citation)

Oil-in-water (O/W) and water-in-oil (W/O) microemulsions of fragrance product formulations are provided. The microemulsions are clear or at least translucent, sprayable, and non-sticky. Novel combinations of anionic surfactant components (a) and hydrophilic coactives (highly water soluble component ...


4
John Hakini, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, January 21, 1997: US05595732 (23 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


5
Mary Helen Binger, Richard Anthony Chizzonite, Richard Allen Kramer, Peter Thomas Lomedico, Stephen J McAndrew, Werner Altenburger: Recombinant coccidiosis vaccines. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, August 26, 1997: US05661015 (16 worldwide citation)

This invention provides DNA sequences coding for Eimeria surface antigens, recombinant vectors containing such DNA sequences, transformed microorganisms containing such vectors, and methods for producing the antigens using the transformed microorganisms. Methods are also provided for protecting poul ...


6
Kurt Bernhard, Jiri Broz, Urs Hengartner, Paul Kreienbuhl, Katharina Schiedt: Pigmentation with carotenoids. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, February 25, 1997: US05605699 (16 worldwide citation)

A method of pigmenting certain parts and products of poultry, fish and crustacea by including in the feed of the pertinent animal one or more of the carotenoids 2'-dehydroplectaniaxanthin, desmethylspheroidenone, spheroidenone, 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydrox ...


7
David Banner, Werner Lesslauer, Hansruedi Lotscher, Dietrich Stuber: Tumor necrosis factor muteins. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, January 28, 1997: US05597899 (14 worldwide citation)

Human TNF muteins having higher binding affinity for human p75-TNF receptor than for human p55-TNF receptor include muteins having at least one different amino acid relative to wild-type human TNF at a position corresponding to position 33, 65, 67, 75, 87, 143, 145 or 147 of the wild-type amino acid ...


8
Georg Frater, Urs Muller, Martin Petrzilka: Odorants. Givaudan Roure, George W Johnston, Catherine R Smith, Mark E Waddell, June 3, 1997: US05635471 (1 worldwide citation)

The invention is concerned with the 7R/7S-diastereoisomer mixture of the formula ##STR1## in pure form, essentially free of the corresponding (4R)-isomers. The invention also concerns the 2R/2S-diastereoisomer mixture of the formula ##STR2## in pure form which is useful as an intermediate for produc ...


9
Mary Helen Binger, Luis Pasamontes: Coccidiosis vaccines. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, November 18, 1997: US05688513

The invention provides an immunogenic polypeptide having the amino acid sequence ##STR1## and fragments thereof, which polypeptides are capable of inducing an immune response against Eimeria parasites, and the DNA encoding such polypeptides, as well as recombinant vectors and recombinant viruses con ...


10
Kevin E B Parkes, Sally Redshaw, Gareth J Thomas: Alcohols. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, December 3, 1996: US05580999

Novel alcohols of the formula ##STR1## wherein R.sup.a is azido or phthalimido, R.sup.4 is alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, R.sup.7 and R.sup.8 together are a trimethylene or tetramethylene group which is optionally substituted by hydroxy, alkoxycarbonylamino or acylamino or in w ...