1
Michael F Clarke, Max S Wicha, Muhammad Al Hajj: Method for treating cancer using a Notch4 ligand antagonist. The Regents of the University of Michigan, Casimir Jones SC, July 13, 2010: US07754206 (31 worldwide citation)

The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4 (D114). The solid tumor may comprise solid tumor stem cells.


2
Gary D Glick: Compositions and methods relating to novel benzodiazepine compounds and derivatives. The Regents of the University of Michigan, Casimir Jones SC, December 29, 2009: US07638624 (18 worldwide citation)

The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agent ...


3
Gary D Glick: Compositions and methods relating to novel compounds and targets thereof. The Regents of the University of Michigan, Casimir Jones SC, December 14, 2010: US07851465 (17 worldwide citation)

The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine compounds, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to ...


4
Gary D Glick: Benzodiazepine compositions for treating epidermal hyperplasia and related disorders. The Regents of the University of Michigan, Casimir Jones SC, March 23, 2010: US07683046 (17 worldwide citation)

The present invention provides, for example, pharmaceutical compositions comprising a benzodiazepine compound and an agent selected from the group consisting of a topical steroid, a keratolytic agent, a topical retinoid, a coal tar, and a vitamin D-3 analog. The pharmaceutical compositions are usefu ...


5
Michael F Clarke, Tim Hoey, Xinhao Wang, Scott Dylla, Austin Gurney, Piero Dalerba, Mark Prince, Grace Chen: Compositions and methods for treating and diagnosing cancer. The Regents of the University of Michigan, OncoMed Pharmaceuticals, Casimir Jones SC, May 25, 2010: US07723112 (15 worldwide citation)

The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of can ...


6
Shaomeng Wang, Ke Ding, Yipin Lu, Zaneta Nikolovska Coleska, Su Qiu, Guoping Wang, Dongguang Qin, Sanjeev Kumar: Small molecule inhibitors of MDM2 and the uses thereof. The Regents of the University of Michigan, Casimir Jones SC, July 20, 2010: US07759383 (15 worldwide citation)

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).


7
Shaomeng Wang, Dongguang Qin, Jiangyong Chen, Shanghai Yu: Indole inhibitors of MDM2 and the uses thereof. The Regents of the University of Michigan, Casimir Jones SC, June 15, 2010: US07737174 (15 worldwide citation)

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).


8
Michael F Clarke, Sean J Morrison, Max S Wicha, Muhammad Al Hajj: Isolation and use of solid tumor stem cells. The Regents of the University of Michigan, Casimir Jones SC, May 11, 2010: US07713710 (14 worldwide citation)

A small percentage of cells within an established tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors ...


9
Gary D Glick, Peter Toogood, Gina Ney: -ATPase inhibitors and related methods, F, Aryl guanidine F. The Regents of the University of Michigan, Casimir Jones SC, July 30, 2013: US08497307 (11 worldwide citation)

The invention provides to a family of aryl guanidine—based F1F0—ATPase inhibitors, e.g., mitochondrial F1F0—ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certain disorders.


10
Gary D Glick, Gina Ney: -ATPase inhibitors and related methods, F, F. The Regents of the University of Michigan, Casimir Jones SC, December 4, 2012: US08324258 (11 worldwide citation)

The present invention relates to a family of guanidine-based F1F0-ATPase inhibitors, e.g., mitochondrial F1F0-ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certain disorders.