1
Aya Jakobovits, Krisztina M Zsebo: Production of antibodies using Cre-mediated site-specific recombination. Abgenix, Japan Tobacco, Carol L Francis, Paula A Bozicevic Field & Francis Borden, October 10, 2000: US06130364 (171 worldwide citation)

A method to produce a cell expressing an antibody from a genomic sequence of the cell comprising a modified immunoglobulin locus using Cre-mediated site-specific recombination is disclosed. The method involves first transfecting an antibody-producing cell with a homology-targeting vector comprising ...


2
Aya Jakobovits, Krisztina M Zsebo: Production of antibodies using Cre-mediated site-specific recombination. Abgenix, Japan Tobacco, Carol L Francis, Paula A Bozicevic Field & Francis Borden, July 18, 2000: US06091001 (157 worldwide citation)

A method to produce a cell expressing an antibody from a genomic sequence of the cell comprising a modified immunoglobulin locus using Cre-mediated site-specific recombination is disclosed. The method involves first transfecting an antibody-producing cell with a homology-targeting vector comprising ...


3
Ronald L Arenson, William V Hassenzahl, Timothy Roberts: Magnetically directable remote guidance systems, and methods of use thereof. The Regents of the University of California, Carol L Francis, Bozicevic Field and Francis, October 16, 2001: US06304769 (131 worldwide citation)

A magnetically directable guidance system useful in, for example, medical magnetic resonance imaging is provided, as well as methods of directing the traverse of a device directable by the remote guidance system to a remote destination. A directable device and methods of use thereof are also disclos ...


4
Edward M Gillis, Felix Theeuwes: Composite drug delivery catheter. Durect Corporation, Carol L Francis, Bozicevic Field and Francis, April 9, 2002: US06368315 (122 worldwide citation)

The present invention features a composite catheter comprising an elongate outer member and an elongate inner member positioned within the outer member so that the inner and outer members define an interstitial space. The outer member has a size and other characteristics that facilitate handling and ...


5
Dennis A Carson, Eyal Raz, Mark Roman: Immunostimulatory polynucleotide/immunomodulatory molecule conjugates. The Regents of the University of California, Carol L Francis, Paula A Borden, Bozicevic Field & Francis, August 26, 2003: US06610661 (121 worldwide citation)

Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which molecule comprises an antigen and may further comprise immunomodulators such as cytokines and adjuvants. ...


6
Eyal R Raz, Hiroko Kobayashi: Method for enhancing an immune response. The Regents of the University of California, Paula A Borden, Carol L Francis, Bozicevic Field & Francis, February 4, 2003: US06514948 (118 worldwide citation)

Disclosed is a method for enhancing an immune response to a substance, such as an antigen or microbial pathogen. The immune response can be, for example, production of IgG2 antibodies. The method comprises administering an immunostimulatory nucleotide sequence (ISS) to a subject at least one hour pr ...


7
Eyal Raz, Richard Kornbluth, Antonio Catanzaro, Tomoko Hayashi, Dennis Carson: Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen. The Regents of the University of California, The United States of America represented by the Department of Veteran Affairs, Carol L Francis, Paula A Borden, Bozicevic Field & Francis, April 22, 2003: US06552006 (105 worldwide citation)

The present invention features methods for treatment or prevention of infection by intracellular pathogens (e.g., Mycobacterium species) by administration of an immunomodulatory nucleic acid molecule. In one embodiment, immunomodulatory nucleic acid molecule are administered in combination with anot ...


8
Sydney Brenner: Methods and compositions for tagging and identifying polynucleotides. Population Genetics Technologies, David C Scherer, Carol L Francis, Bozicevic Field & Francis, July 1, 2008: US07393665 (103 worldwide citation)

The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index ...


9
Steve E Lincoln, Tod M Klingler, Janice Au Young, Y Tom Tang, Richard D Goold, Ingrid E Akerblom, Jeffrey J Seilhamer, Phillip R Hawkins, Lynn E Murry, Angelo M Delegeane, Wendy B Levine, Jennifer L Hillman, Surya K Goli, Christina M Altus, Olga Bandman, Samuel T LaBrie, Purvi Shah: Database for storage and analysis of full-length sequences. Incyte Pharmaceuticals, Carol L Francis, Bozicevic Field & Francis, October 16, 2001: US06303297 (101 worldwide citation)

The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between inf ...


10
Irving K Arenberg, Michael H Arenberg: Fluid transfer and diagnostic system for treating the inner ear. Durect Corporation, Carol L Francis, Paula A Borden, Bozicevic Field & Francis, August 27, 2002: US06440102 (99 worldwide citation)

An apparatus for delivering fluid materials into and out of the inner ear via the round window membrane. A fluid transfer conduit is provided which includes one or more passageways therethrough which may have a semipermeable membrane associated therewith to control fluid flow. Attached to the condui ...