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Robert S Langer, David M Lynn, David Putnam, Mansoor M Amiji, Daniel G Anderson: Biodegradable poly(β-amino esters) and uses thereof. Massachusetts Institute of Technology, Brenda Herschbach Jarrell, C Hunter Baker, Choate Hall & Stewart, February 14, 2006: US06998115 (61 worldwide citation)

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably b ...


2
Kerry Peter Mahon, Kevin Thomas Love, Christopher G Levins, Kathryn Ann Whitehead, Robert S Langer, Daniel Griffith Anderson: Aminoalcohol lipidoids and uses thereof. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, May 28, 2013: US08450298 (54 worldwide citation)

Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxi ...


3
Robert S Langer, David M Lynn, David Putnam, Mansoor M Amiji, Daniel G Anderson: Biodegradable poly(beta-amino esters) and uses thereof. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, October 15, 2013: US08557231 (52 worldwide citation)

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably b ...


4
Lawrence A Shimp, David Knaack: Coupling agents for orthopedic biomaterials. Osteotech, Choate Hall & Stewart, C Hunter Baker, September 18, 2007: US07270813 (46 worldwide citation)

The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an ost ...


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Daniel G Anderson, David M Lynn, Akin Akinc, Robert S Langer: Biodegradable poly(β-amino esters) and uses thereof. Massachusetts Institute of Technology, The United States of Americas represented by the Secretary of the Army, Choate Hall & Stewart, C Hunter Baker, September 23, 2008: US07427394 (45 worldwide citation)

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably b ...


6
Terence S Russell: Nucleic acid sequencing using an optically labeled pore. LifeBeam Technologies, Brenda Herschbach Jarrell, C Hunter Baker, Choate Hall & Stewart, March 4, 2003: US06528258 (43 worldwide citation)

The present invention provides a system for analyzing polymer molecules by detecting their effects on an optical agent. Certain preferred embodiments of the invention involve the analysis of polynucleotide molecules through detection of their quenching effects on a fluorescent reporter.


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Stuart L Schreiber, Scott M Sternson, Jason C Wong, Christina M Grozinger, Stephen J Haggarty, Kathryn M Koeller: Dioxanes and uses thereof. President and Fellows of Harvard College, Choate Hall & Stewart, C Hunter Baker, July 17, 2007: US07244853 (38 worldwide citation)

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2, R3, n, X and Y are as defined herein. The presen ...


9
Jun O Liu, Eric C Griffith, Zhuang Su: Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof. Massachusetts Institute of Technology, Brenda Herschbach Jarrell, C Hunter Baker, Choate Hall & Stewart, May 20, 2003: US06566541 (33 worldwide citation)

Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure ...


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Tushar A Kshirsagar, Gregory D Lundquist, David T Amos, Joseph F Dellaria Jr, Bernhard M Zimmermann, Philip D Heppner: Oxime substituted imidazoquinolines. 3M Innovative Properties Company, Wolf Greenfield & Sacks P C, C Hunter Baker, March 1, 2011: US07897767 (30 worldwide citation)

Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulato ...