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Nicholas I Payne, J Roger Salmon: Spray-drying method for preparing liposomes and products produced thereby. E R Squibb & Sons, Burton Rodney, May 16, 1989: US04830858 (126 worldwide citation)

A method is provided for preparing a stable liposome precursor in the form of a mixture of spray-dried liposomal components including one or more biologically active compounds which may be stored dry and reconstituted with water to form a liposomal preparation immediately prior to use. The dry lipos ...


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Scott A Biller, John K Dickson, R Michael Lawrence, David R Magnin, Michael A Poss, Jeffrey A Robl, William A Slusarchyk, Richard B Sulsky, Joseph A Tino: Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method. Burton Rodney, June 2, 1998: US05760246 (115 worldwide citation)

Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2;


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William N Washburn, Ravindar N Girotra, Philip M Sher, Amarendra B Mikkilineni, Kathleen M Poss, Arvind Mathur, Gregory S Bisacchi, Ashvinikumar V Gavai: Catecholamine surrogates useful as .beta..sub.3 agonists. Bristol Myers Squibb Company, Burton Rodney, July 7, 1998: US05776983 (114 worldwide citation)

Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH.sub.2).sub.n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R.sup.9)R.sup.9' or --CO.sub.2 R.sup.7 ;


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Nemichand B Jain, Linda P Gertie, Edward M Rudnic: Controlled release formulation. E R Squibb & Sons, Lawrence S Levinson, Burton Rodney, September 9, 1986: US04610870 (113 worldwide citation)

A controlled release pharmaceutical formulation which undergoes substantially or approaches zero order release of active drug is provided, preferably in the form of a coated tablet, containing a core portion from which medicament, such as procainamide hydrochloride, is slowly released over a control ...


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Andrew Dennis, Peter Timmins, Kevin Lee: Buoyant controlled release powder formulation. E R Squibb & Sons, Burton Rodney, December 8, 1992: US05169638 (108 worldwide citation)

A buoyant controlled release pharmaceutical powder formulation is provided which may be filled into capsules and releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight o ...


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John R Howard, Peter Timmins: Controlled release formulation. E R Squibb & Sons, Lawrence S Levinson, Burton Rodney, December 20, 1988: US04792452 (107 worldwide citation)

A controlled release pharmaceutical formulation is provided which releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alg ...


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George B Mackaness, Joseph P Hou: Contrast media containing liposomes as carriers. E R Squibb & Sons, Lawrence S Levinson, Burton Rodney, March 11, 1980: US04192859 (105 worldwide citation)

X-Ray contrast media are provided containing an X-ray contrast agent such as N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)am ino]-2,4,6-triiodo-1,3-benzenedicarboxamide, sodium diatrizoate, meglumine diatrizoate, sodium iodipamide, meglumine iodipamide and the like, and a lip ...


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Scott A Biller, John K Dickson, R Michael Lawrence, David R Magnin, Michael A Poss, Richard B Sulsky, Joseph A Tino: Inhibitors of microsomal triglyceride transfer protein and method. Bristol Myers Squibb Company, Burton Rodney, April 14, 1998: US05739135 (103 worldwide citation)

Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.