1
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Briana C Buchholz, December 15, 1998: US05849860 (99 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


2
Navnit Hargovindas Shah, Aruna M Railkar, Wantanee Phuapradit: Colon targeted delivery system. Hoffman La Roche, George W Johnston, William H Epstein, Briana C Buchholz, March 21, 2000: US06039975 (92 worldwide citation)

A novel delivery system for targeting drugs to the colon is herein described. The system is a tablet comprised of three parts: 1) an outer enteric coating, 2) an inner semi-permeable polymer membrane containing a plasticizer and 3) a central core comprising swelling excipients and an active ingredie ...


3
Gottfried Alber, Jacqueline Anne Carr, Frank Albert Mattner, Michael John Mulqueen, Kathrin Palmer, Jane Andre Louise Rogerson: Use of IL-12 and IFN.alpha. for the treatment of infectious diseases. Hoffmann La Roche, George W Johnson, William H Epstein, Briana C Buchholz, July 27, 1999: US05928636 (54 worldwide citation)

The present invention provides a combination of IL-12 and IFN.alpha. together with a pharmaceutically acceptable carrier useful for treatment and prophylaxis of infectious diseases, preferably chronic infectious diseases and more preferably viral infections, e.g. HSV, HIV, Hepatitis B, Hepatitis C, ...


4
Maurice Kent Gately, Ulrich Andreas Gubler, Jeffrey David Hulmes, Frank John Podlaski, Alvin Seth Stern, Richard Anthony Chizzonite, Yu Ching Eugene Pan: Monoclonal antibodies to cytotoxic lymphocyte maturation factor. Hoffmann La Roche, George W Johnston, William H Epstein, Briana C Buchholz, July 14, 1998: US05780597 (34 worldwide citation)

The present invention relates to antibodies which bind to a novel cytotoxic lymphocyte maturation factor. When bound to the cytotoxic lymphocyte maturation factor, the antibodies can neutralize bioactivity of the factor.


5
Kanakaraju Koduri, John T Miller, Pallaiah Thammana: Expression vectors containing hot spot for increased recombinant protein expression in transfected cells. Briana C Buchholz, Audrey F Sher, Christopher A Klein, February 18, 2003: US06521419 (28 worldwide citation)

A specific locus (hot spot) for recombinant gene expression has been identified in the genome of Chinese hamster ovary cells. A DNA vector containing the hot spot causes high levels of recombinant gene expression following transfection and stable integration. The selection and cloning of the specifi ...


6
Jacques Bailly, Andre Fleury, Paul Hadvary, Hans Lengsfeld, Hans Steffen: Pharmaceutical composition containing chitosan. Hoffmann La Roche, George W Johnson, William H Epstein, Briana C Buchholz, February 29, 2000: US06030953 (16 worldwide citation)

The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of chitosan, its derivatives and salts thereof. Methods are provided for preventing and treating anal leaka ...


7
Kanaka Raju Koduri, John T Miller, Pallaiah Thammana: Expression vectors containing hot spot for increased recombinant protein expression in transfected cells. Bristol Myers Squibb Company, Briana C Buchholz, Christopher A Klein, October 5, 2004: US06800457 (13 worldwide citation)

A specific locus (hot spot) for recombinant gene expression has been identified in the genome of Chinese hamster ovary cells. A DNA vector containing the hot spot causes high levels of recombinant gene expression following transfection and stable integration. The selection and cloning of the specifi ...


8
Joseph Armstrong Martin, Bradley Stuart Sherborne, Gareth Mark Taylor: Acridine derivatives. Hoffmann La Roche, George W Johnston, William H Epstein, Briana C Buchholz, October 19, 1999: US05969139 (4 worldwide citation)

The invention relates to new and known tricyclic dione derivatives of the general formula ##STR1## wherein W represents hydrogen or lower alkyl;


9
Michael A Blanar, Paul C Levesque, Wayne A Little, Michael G Neubauer, Wen Pin Yang: KCNQ potassium channels and methods of modulating same. Bristol Myers Squibb Company, Briana C Buchholz, Christopher A Klein, June 11, 2002: US06403360 (4 worldwide citation)

The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neu ...


10
Richard Anthony Chizzonite, Theresa Patricia Truitt: Antibody to IL-12 receptor. Hoffmann La Roche, George W Johnston, William H Epstein, Briana C Buchholz, April 4, 2000: US06046012 (3 worldwide citation)

This disclosure relates to novel antibodies specific to the recently discovered receptor to human interleukin 12 (IL-12R). The antibodies to IL-12R, most preferably, the monoclonal antibodies to that protein, are useful in determining the status of the human immune system and as diagnostic reagents ...