1
G John Pritchard, Joseph E Bateson, Brian S Hill, Brian A Heald, Scott E Hubbard: Electrochemical biosensor test strip. Boehringer Mannheim Corporation, D Michael Young, Max J Kenemore, Brent A Harris, June 9, 1998: US05762770 (360 worldwide citation)

An electrochemical biosensor test strip that has a minimum volume blood sample requirement of about 9 microliters. The test strip has working and counter electrodes that are substantially the same size and made of the same electrically conducting material placed on a first insulating substrate. Over ...


2
Zhi David Deng, Gerald F Sigler, Nigel A Surridge, Christopher D Wilsey, Robert J McEnroe, Walter W Jernigan, Rebecca W Muddiman: Reagent including an osmium-containing redox mediator. Boehringer Mannheim Corporation, D Michael Young, Max J Kenemore, Brent A Harris, December 8, 1998: US05846702 (210 worldwide citation)

A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) excellent solu ...


3
Wolfgang Schwobel, Bernd Hein: Process for the production of analytical devices. Roche Diagnostics, Brent A Harris, Roche Diagnostics Corporation, March 27, 2001: US06207000 (47 worldwide citation)

A process for the production of analytical devices is provided in accordance with the present invention. Analytical devices include analytical test elements with a capillary-active zone for examining liquid samples. In the process a carrier layer is prepared, a spacer layer is laminated onto the car ...


4
Francis E Dwulet, Marilyn E Smith: Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease. Boehringer Mannheim Corporation, Brent A Harris, D Michael Young, Marilyn L Amick, November 3, 1998: US05830741 (30 worldwide citation)

An enzyme composition for dissociating tissues is disclosed. The composition comprises purified collagenase I and collagenase II from Clostridium histolyticum in a mass ratio of about 0.3 to 0.6 and a neutral protease such that the ratio of total FITC casein units of activity to Wunsch units of acti ...


5
Francis E Dwulet, Bernice B Ellis, John F Gill, Linda B Jacobsen, Marilyn E Smith, David G Waters: Purified mixture of collagenase I, collagenase II and two other proteases. Boehringer Mannheim Corporation, Brent A Harris, D Michael Young, Marilyn L Amick, May 19, 1998: US05753485 (17 worldwide citation)

A purified enzyme mixture useful for isolating cells or cell clusters from tissue is disclosed. The mixture includes at least two collagenase enzymes, at least two other proteases, and additional non-protease components. The mixture is purified by removing at least some of the non-protease component ...


6
Francis E Dwulet, Bernice B Ellis, John F Gill, Linda B Jacobsen, Marilyn E Smith, David G Waters: Purified mixture of collagenase I, collagenase II and two other proteases. Roche Diagnostics Corporation, Brent A Harris, November 23, 1999: US05989888 (14 worldwide citation)

A purified enzyme mixture useful for isolating cells or cell clusters from tissue is disclosed. The mixture includes at least two collagenase enzymes, at least two other proteases, and additional non-protease components. The mixture is purified by removing at least some of the non-protease component ...


7
Volker Keller, Andreas Rauscher, Joachim Steinbiss, Reiner Schlipfenbacher, Jurgen Klepp: Analytical element for species-specific detection of nucleic acids. Roche Diagnostics, Brent A Harris, Jill L Woodburn, November 26, 2002: US06485915 (4 worldwide citation)

The present invention concerns a method for the detection of nucleic acids on an analytical element which contains a sample application zone and a detection zone, the analytical element enabling liquid transport from the sample application zone to the detection zone, wherein a sample is applied to t ...


8
Bernhard Schaffar, Herbert Kroneis, Taghi Noormofidi, Gernot Florian, Wolf Dietrich Steinbock: Creatinine sensor calibration. Brent A Harris, Roche Diagnostics Corporation, April 15, 2004: US20040072277-A1

In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring ...


9
Guenter Frey, Norbert Ladiges, Siegfried Noetzel, Bernd Roesicke: Device for separating and discharging plasma. Brent A Harris, Roche Diagnostics Corporation, November 11, 2004: US20040222168-A1

The invention concerns plasma separation on a microliter scale. The method/system according to the invention is able to provide plasma in the range of several microliters within a very short time as it is required, for example, in modern analyses by carrier-bound test elements. Plasma separation and ...


10
Thomas Walter: Method and device for purifying nucleic acids. Brent A Harris, Roche Diagnostics Corporation, August 26, 2004: US20040166524-A1

A devise for isolating nucleic acids which reduces the transfer of contaminants during nucleic acid isolation methods which is composed of two vessels which are linked by a closing element in which a material that binds nucleic acids is placed. The nucleic acid can for example be bound to the materi ...