1
Giorgio Cirelli, Hans Steffen, Christian Surber: Portable injection appliance. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, A Kate Huffmann, December 12, 1989: US04886499 (460 worldwide citation)

The portable appliance is of use for the subcutaneous or intradermal injection of a liquid formulation of an active principle and it comprises in combination: a supply vessel for the formulation; an injection needle adapted to communicate with the vessel; pump means for emptying the vessel through t ...


2
Michael Klaus, Peter Mohr, Ekkehard Weiss: Condensed heterocyclic compounds. Hoffmann La Roche, George M Gould, Bernard S Leon, William G Isgro, August 6, 1991: US05037825 (122 worldwide citation)

The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, acyl, lower-alkyl or --CHO, --CH.sub.2 OR.sup.10, --COR.sup.7 or OR.sup.13 ; R.sup.2, R.sup.3 and R.sup.4 are, independently, hydrogen, lower-alkyl, lower-alkoxy or halogen; R.sup.5 and R.sup.6 are, independently ...


3
Arthur Boller, Martin Schadt, Alois Villiger: Hydrogenated naphthalenes. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, William G Isgro, July 5, 1983: US04391731 (118 worldwide citation)

Compounds of the formula ##STR1## wherein ring A is saturated or aromatic and a saturated ring A which may be present is trans-linked with the second ring; R.sup.1 is a straight-chain alkyl or alkoxy group containing 1 to 11 carbon atoms; R.sup.2 is cyano, a straight-chain alkyl group containing 1 t ...


4
Hendrik G Stunnenberg, Riccardo Wittek: Vaccinia DNA. Hoffmann La Roche, George M Gould, Bernard S Leon, William H Epstein, May 21, 1991: US05017487 (116 worldwide citation)

New transcriptional regulatory sequences useful in the expression of pro- or eukaryotic proteins in eukaryotic organisms are provided comprising the 5' flanking region of the vaccinia virus late 11 kDa gene. Also described are recombinant vectors and recombinant infectious poxviruses containing such ...


5
Peter D Davis, Christopher H Hill, Geoffrey Lawton: Substituted pyrroles. Hoffmann La Roche, George M Gould, Bernard S Leon, Ellen Ciambrone Coletti, October 15, 1991: US05057614 (114 worldwide citation)

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Y have the signficance given in the description, are useful in the control or prevention of inflammatory, immunological, bronchopulmonary or cardiovascular disorders.


6
Paul Hadvary, Erich Hochuli, Ernst Kupfer, Hans Lengsfeld, Ernst K Weibel: Leucine derivatives. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, George W Johnston, July 1, 1986: US04598089 (107 worldwide citation)

Novel compounds of the formula ##STR1## wherein A signifies the group ##STR2## or --(CH.sub.2).sub.5 --, which inhibit pancreas lipase and can be used for the control or prevention of obesity and hyperlipaemia, are disclosed. The inventive compounds can be produced by the cultivation of microorganis ...


7
Raphael J Mannino, Susan G Fogerite: Liposome methods and compositions. Jon S Saxe, Bernard S Leon, George M Gould, May 5, 1987: US04663161 (97 worldwide citation)

The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an efficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles with a large, internal aqueous space. The method ...


8
Edward J Lombardi Jr, Harold L Neuman, Alfred E Magro, Michael L Rishton: Percutaneous intra-aortic balloon apparatus. Kontron Cardiovascular, Jon S Saxe, Bernard S Leon, George W Johnston, December 7, 1982: US04362150 (87 worldwide citation)

Intra-aortic balloon apparatus is disclosed including a single chamber balloon sealably attached to the end of a catheter for non-surgical insertion into the aorta through the skin as by the standard Seldinger technique. In the preferred embodiment, the extreme end of the balloon is fixedly attached ...


9
William A Fox: Tray for immunometric determinations. Hoffmann La Roche, George M Gould, Bernard S Leon, William H Epstein, August 20, 1991: US05041266 (86 worldwide citation)

A microtiter plate containing a plurality of reaction wells for conducting immunogenic reactions wherein the bottom wall of the reaction well has an inner surface which is substantially hydrophilic, and the side wall of the reaction well has an inner surface which is substantially hydrophobic and a ...


10
Michael F Holick, Milan R Uskokovic: Administration of biologically active vitamin D.sub.3 and vitamin D.sub.2 materials. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, William H Epstein, October 28, 1980: US04230701 (86 worldwide citation)

A process for administering biologically active vitamin D.sub.3 and vitamin D.sub.2 materials into the blood system of a subject by providing the biologically active vitamin D.sub.3 or D.sub.2 material to the skin whereby the skin releases the biologically active vitamin D.sub.3 or D.sub.2 material ...